Feline Polycystic Kidney Disease: An Update

Polycystic kidney disease (PKD) is a disease that affects felines and other mammals, such as humans. The common name is autosomal dominant polycystic kidney disease (ADPKD) and causes a progressive development of fluid-filled cysts in the kidney and sometimes in other organs as the liver and pancrea...

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Autores principales:	Lorie Schirrer, Pablo Jesús Marín-García, Lola Llobat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cat control disease feline polycystic kidney disease hereditary pathology Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/c666515ddc784a27901c6d1a73c634f6
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spelling	oai:doaj.org-article:c666515ddc784a27901c6d1a73c634f62021-11-25T19:12:01ZFeline Polycystic Kidney Disease: An Update10.3390/vetsci81102692306-7381https://doaj.org/article/c666515ddc784a27901c6d1a73c634f62021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/269https://doaj.org/toc/2306-7381Polycystic kidney disease (PKD) is a disease that affects felines and other mammals, such as humans. The common name is autosomal dominant polycystic kidney disease (ADPKD) and causes a progressive development of fluid-filled cysts in the kidney and sometimes in other organs as the liver and pancreas. The formation and growth of cysts progress slowly, causing deterioration of kidney tissue and a gradual decrease in kidney function, leading to irreversible kidney failure. Feline PKD or ADPKD in humans are hereditary pathologies of autosomal dominant transmission. ADPKD is one of the genetic diseases with the highest prevalence in humans. In cats, this disease also has a high prevalence, mainly in the Persian breed, being one of the most common feline genetic diseases. Imaging tests seem to be the most reliable method for diagnosis of the disease, although more genetic tests are being developed to detect the presence of the responsible mutation. In this review, we summarize the current knowledge about feline PKD to guide future research related to an adequate diagnosis and early detection of causal mutations. It can allow the establishment of selection programs to reduce or eliminate this pathology in feline breeds.Lorie SchirrerPablo Jesús Marín-GarcíaLola LlobatMDPI AGarticlecatcontrol diseasefeline polycystic kidney diseasehereditary pathologyVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 269, p 269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cat control disease feline polycystic kidney disease hereditary pathology Veterinary medicine SF600-1100
spellingShingle	cat control disease feline polycystic kidney disease hereditary pathology Veterinary medicine SF600-1100 Lorie Schirrer Pablo Jesús Marín-García Lola Llobat Feline Polycystic Kidney Disease: An Update
description	Polycystic kidney disease (PKD) is a disease that affects felines and other mammals, such as humans. The common name is autosomal dominant polycystic kidney disease (ADPKD) and causes a progressive development of fluid-filled cysts in the kidney and sometimes in other organs as the liver and pancreas. The formation and growth of cysts progress slowly, causing deterioration of kidney tissue and a gradual decrease in kidney function, leading to irreversible kidney failure. Feline PKD or ADPKD in humans are hereditary pathologies of autosomal dominant transmission. ADPKD is one of the genetic diseases with the highest prevalence in humans. In cats, this disease also has a high prevalence, mainly in the Persian breed, being one of the most common feline genetic diseases. Imaging tests seem to be the most reliable method for diagnosis of the disease, although more genetic tests are being developed to detect the presence of the responsible mutation. In this review, we summarize the current knowledge about feline PKD to guide future research related to an adequate diagnosis and early detection of causal mutations. It can allow the establishment of selection programs to reduce or eliminate this pathology in feline breeds.
format	article
author	Lorie Schirrer Pablo Jesús Marín-García Lola Llobat
author_facet	Lorie Schirrer Pablo Jesús Marín-García Lola Llobat
author_sort	Lorie Schirrer
title	Feline Polycystic Kidney Disease: An Update
title_short	Feline Polycystic Kidney Disease: An Update
title_full	Feline Polycystic Kidney Disease: An Update
title_fullStr	Feline Polycystic Kidney Disease: An Update
title_full_unstemmed	Feline Polycystic Kidney Disease: An Update
title_sort	feline polycystic kidney disease: an update
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c666515ddc784a27901c6d1a73c634f6
work_keys_str_mv	AT lorieschirrer felinepolycystickidneydiseaseanupdate AT pablojesusmaringarcia felinepolycystickidneydiseaseanupdate AT lolallobat felinepolycystickidneydiseaseanupdate
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Feline Polycystic Kidney Disease: An Update

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