Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer

Abstract Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend th...

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Autores principales:	Lars Bäckman, Otto Waris, Jarkko Johansson, Micael Andersson, Juha O. Rinne, Kati Alakurtti, Anna Soveri, Matti Laine, Lars Nyberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c66a0371cf284bf184b439d7da1f786e
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spelling	oai:doaj.org-article:c66a0371cf284bf184b439d7da1f786e2021-12-02T12:31:50ZIncreased dopamine release after working-memory updating training: Neurochemical correlates of transfer10.1038/s41598-017-07577-y2045-2322https://doaj.org/article/c66a0371cf284bf184b439d7da1f786e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07577-yhttps://doaj.org/toc/2045-2322Abstract Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findings by also examining neurochemical correlates of transfer. Four positron emission tomography (PET) scans using the radioligand raclopride were performed. Two of these assessed DAD2 binding (letter memory; n-back) before 5 weeks of updating training, and the same two scans were performed post training. Key findings were (a) pronounced training-related behavioral gains in the letter-memory criterion task, (b) altered striatal DAD2 binding potential after training during letter-memory performance, suggesting training-induced increases in DA release, and (c) increased striatal DA activity also during the n-back transfer task after the intervention, but no concomitant behavioral transfer. The fact that the training-related DA alterations during the transfer task were not accompanied by behavioral transfer suggests that increased DA release may be a necessary, but not sufficient, condition for behavioral transfer to occur.Lars BäckmanOtto WarisJarkko JohanssonMicael AnderssonJuha O. RinneKati AlakurttiAnna SoveriMatti LaineLars NybergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lars Bäckman Otto Waris Jarkko Johansson Micael Andersson Juha O. Rinne Kati Alakurtti Anna Soveri Matti Laine Lars Nyberg Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
description	Abstract Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findings by also examining neurochemical correlates of transfer. Four positron emission tomography (PET) scans using the radioligand raclopride were performed. Two of these assessed DAD2 binding (letter memory; n-back) before 5 weeks of updating training, and the same two scans were performed post training. Key findings were (a) pronounced training-related behavioral gains in the letter-memory criterion task, (b) altered striatal DAD2 binding potential after training during letter-memory performance, suggesting training-induced increases in DA release, and (c) increased striatal DA activity also during the n-back transfer task after the intervention, but no concomitant behavioral transfer. The fact that the training-related DA alterations during the transfer task were not accompanied by behavioral transfer suggests that increased DA release may be a necessary, but not sufficient, condition for behavioral transfer to occur.
format	article
author	Lars Bäckman Otto Waris Jarkko Johansson Micael Andersson Juha O. Rinne Kati Alakurtti Anna Soveri Matti Laine Lars Nyberg
author_facet	Lars Bäckman Otto Waris Jarkko Johansson Micael Andersson Juha O. Rinne Kati Alakurtti Anna Soveri Matti Laine Lars Nyberg
author_sort	Lars Bäckman
title	Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
title_short	Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
title_full	Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
title_fullStr	Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
title_full_unstemmed	Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
title_sort	increased dopamine release after working-memory updating training: neurochemical correlates of transfer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c66a0371cf284bf184b439d7da1f786e
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Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer

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