Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs

The genus Salvia L. has more than 900 species distributed throughout the globe. 21 species are growing in Ukraine. All species of this genus have essential oils. Salvia officinalis and Salvia sclarea have been used in the culture and are widely used in medical practice. The chemical composition of o...

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Autores principales:	Mykhailo Myha, Oleh Koshovyi, Yevhen Karpun, Alla Kovaleva, Olga Mala, Volodymyr Parchenko, Oleksandr Panasenko, Vera Bunyatyan, Sergiy Kovalenko
Formato:	article
Lenguaje:	EN
Publicado:	PC Technology Center 2021
Materias:	salvia leaves flowers stems terpenes chromato-mass spectrometry Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/c66b2d482b6345018053d8c474ab4e46
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spelling	oai:doaj.org-article:c66b2d482b6345018053d8c474ab4e462021-11-04T14:22:47ZChromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs2519-48442519-485210.15587/2519-4852.2021.242761https://doaj.org/article/c66b2d482b6345018053d8c474ab4e462021-10-01T00:00:00Zhttp://journals.uran.ua/sr_pharm/article/view/242761https://doaj.org/toc/2519-4844https://doaj.org/toc/2519-4852The genus Salvia L. has more than 900 species distributed throughout the globe. 21 species are growing in Ukraine. All species of this genus have essential oils. Salvia officinalis and Salvia sclarea have been used in the culture and are widely used in medical practice. The chemical composition of other species of sage and the possibility of their use in pharmaceutical and medical practice are almost not studied. Taking into account the results of chemotaxonomic studies of species of the flora genus of Ukraine, their prevalence and prospects for introduction into the culture, for further studies were selected raw materials of S. grandiflora, S. pratensis and S. verticillata. The aim. The aim of the study was to conduct a chromato-mass spectrometric study of the aboveground organs of S. grandiflora L., S. pratensis L. and S. verticillata L. to establish the prospects for the use of raw materials of these species in medical and pharmaceutical practice. Materials and methods. The objects of the study were leaves of S. officinalis, leaves, stems and flowers of S. grandiflora, S. pratensis and S. verticillata, which were harvested on the basis of the botanical garden of Ivan Franko National University of Lviv. The research of volatile substances in the objects of the research was carried out by the method of GC-MS on the basis of the Department of Natural Sciences for Foreign Students and Toxicological Chemistry of Zaporizhia State Medical University. Results. As a result of the study, 243 substances were found in the objects of the study, of which 149 were identified. 77 substances were found in the leaves of S. officinalis, 80, 26 and 63 substances in the leaves, stems and flowers of S. grandiflora, respectively, in the leaves , stems and flowers of S. pratensis – 28, 30 and 48 substances, respectively, in leaves, stems and flowers of S. verticillata – 39, 22 and 39 substances, respectively. Dominant compounds among substances of terpenoid nature are: cyclofenchene, camphene, 1,8-cineole, α-thujone, β-thujone, camphor borneol, caryophyllene, humulene, viridiflorol, sabinene, pyranone, β-pinene, phytol, kolavenol, β-copaen, loliolide, pseudolimonene and spatulenol. Among the dominant substances, 8 were detected for the first time in these species: cyclofenchene, viridiflorol, sabinene, pyranone, phytol, kolavenol, loliolide and pseudolimonene. Conclusions. The leaves of S. officinalis, leaves, stems and flowers of S. grandiflora, S. pratensis and S. verticillata of the flora of Ukraine were studied by chromato-mass spectrometric method. As a result of the study, 243 substances were identified, of which 149 were identified. Promising raw materials containing terpene compounds for S. grandiflora there are leaves, and for S. pratensis and S. verticillata – flowers, so they are promising agents for introduction into pharmaceutical practiceMykhailo MyhaOleh KoshovyiYevhen KarpunAlla KovalevaOlga MalaVolodymyr ParchenkoOleksandr PanasenkoVera BunyatyanSergiy KovalenkoPC Technology Centerarticlesalvialeavesflowersstemsterpeneschromato-mass spectrometryPharmacy and materia medicaRS1-441ENScienceRise: Pharmaceutical Science, Iss 5(33), Pp 32-40 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	salvia leaves flowers stems terpenes chromato-mass spectrometry Pharmacy and materia medica RS1-441
spellingShingle	salvia leaves flowers stems terpenes chromato-mass spectrometry Pharmacy and materia medica RS1-441 Mykhailo Myha Oleh Koshovyi Yevhen Karpun Alla Kovaleva Olga Mala Volodymyr Parchenko Oleksandr Panasenko Vera Bunyatyan Sergiy Kovalenko Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs
description	The genus Salvia L. has more than 900 species distributed throughout the globe. 21 species are growing in Ukraine. All species of this genus have essential oils. Salvia officinalis and Salvia sclarea have been used in the culture and are widely used in medical practice. The chemical composition of other species of sage and the possibility of their use in pharmaceutical and medical practice are almost not studied. Taking into account the results of chemotaxonomic studies of species of the flora genus of Ukraine, their prevalence and prospects for introduction into the culture, for further studies were selected raw materials of S. grandiflora, S. pratensis and S. verticillata. The aim. The aim of the study was to conduct a chromato-mass spectrometric study of the aboveground organs of S. grandiflora L., S. pratensis L. and S. verticillata L. to establish the prospects for the use of raw materials of these species in medical and pharmaceutical practice. Materials and methods. The objects of the study were leaves of S. officinalis, leaves, stems and flowers of S. grandiflora, S. pratensis and S. verticillata, which were harvested on the basis of the botanical garden of Ivan Franko National University of Lviv. The research of volatile substances in the objects of the research was carried out by the method of GC-MS on the basis of the Department of Natural Sciences for Foreign Students and Toxicological Chemistry of Zaporizhia State Medical University. Results. As a result of the study, 243 substances were found in the objects of the study, of which 149 were identified. 77 substances were found in the leaves of S. officinalis, 80, 26 and 63 substances in the leaves, stems and flowers of S. grandiflora, respectively, in the leaves , stems and flowers of S. pratensis – 28, 30 and 48 substances, respectively, in leaves, stems and flowers of S. verticillata – 39, 22 and 39 substances, respectively. Dominant compounds among substances of terpenoid nature are: cyclofenchene, camphene, 1,8-cineole, α-thujone, β-thujone, camphor borneol, caryophyllene, humulene, viridiflorol, sabinene, pyranone, β-pinene, phytol, kolavenol, β-copaen, loliolide, pseudolimonene and spatulenol. Among the dominant substances, 8 were detected for the first time in these species: cyclofenchene, viridiflorol, sabinene, pyranone, phytol, kolavenol, loliolide and pseudolimonene. Conclusions. The leaves of S. officinalis, leaves, stems and flowers of S. grandiflora, S. pratensis and S. verticillata of the flora of Ukraine were studied by chromato-mass spectrometric method. As a result of the study, 243 substances were identified, of which 149 were identified. Promising raw materials containing terpene compounds for S. grandiflora there are leaves, and for S. pratensis and S. verticillata – flowers, so they are promising agents for introduction into pharmaceutical practice
format	article
author	Mykhailo Myha Oleh Koshovyi Yevhen Karpun Alla Kovaleva Olga Mala Volodymyr Parchenko Oleksandr Panasenko Vera Bunyatyan Sergiy Kovalenko
author_facet	Mykhailo Myha Oleh Koshovyi Yevhen Karpun Alla Kovaleva Olga Mala Volodymyr Parchenko Oleksandr Panasenko Vera Bunyatyan Sergiy Kovalenko
author_sort	Mykhailo Myha
title	Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs
title_short	Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs
title_full	Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs
title_fullStr	Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs
title_full_unstemmed	Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs
title_sort	chromato-mass-spectrometric research in salvia grandiflora l., salvia pratensis l. and salvia verticillata l. aboveground organs
publisher	PC Technology Center
publishDate	2021
url	https://doaj.org/article/c66b2d482b6345018053d8c474ab4e46
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Chromato-mass-spectrometric research in Salvia grandiflora L., Salvia pratensis L. and Salvia verticillata L. aboveground organs

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