CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT

It is known at the present time that immunological biomarkers may become more sensitive, non-invasive methods of graft rejection diagnosis than those currently used. A growing amount of studies in animal models shows that chemokines, as active participants in the immune process, may be used to this...

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Autores principales:	T. V. Fedorenko, N. V. Kolesnikova, I. A. Pashkova, V. A. Porhanov, E. A. Gubareva, E. V. Kuevda
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	kidney transplantation chemokines allograft rejection transplantation immunity biomarker Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c6710467511d4d46be502991979d5ced
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spelling	oai:doaj.org-article:c6710467511d4d46be502991979d5ced2021-11-18T08:03:48ZCHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT1563-06252313-741X10.15789/1563-0625-2019-4-749-754https://doaj.org/article/c6710467511d4d46be502991979d5ced2019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1625https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIt is known at the present time that immunological biomarkers may become more sensitive, non-invasive methods of graft rejection diagnosis than those currently used. A growing amount of studies in animal models shows that chemokines, as active participants in the immune process, may be used to this purpose. Our earlier studies have shown an important prognostic significance of IL-6, IL-2, 17A and IL-1RA increase in pre-operative period as markers of acute kidney allograft rejection. When assessing changes in studied peripheral blood growth factors, we concluded that a sharp decrease in BDNF content is a diagnostically significant early sign of kidney allograft rejection. The aim of this study was to identify the prognostic role of serum chemokine levels at the preoperative stage, taking into account the production of anti-HLA antibodies during the post-transplant period as a risk factor of kidney allograft rejection. A comparative analysis of chemokine serum concentrations was performed in the patients with terminal-stage chronic kidney disease (CKD). In the patients from main clinical groups, the blood cytokine levels were measured 6 hours before transplantation, i.e., Eotaxin (CCL11), GRO-α (CXCL1), IL-8 (CXCL8), IP-10 (CXCL10), MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4), SDF-1α (CXCL12), RANTES (CCL5), MIG (CXCL9) by means of multiplex immunological assays, using appropriate test systems. The studies have shown significant changes in several chemokines in the CKD patients compared to age-matched controls. However, the following diagnostically significant biomarkers associated with early rejection of transplanted kidney should be considered: increased concentration of CCL2 and CCL4 chemokines, as well as an acute decrease in CCL11. Significantly decreased CXCL12 concentration in peripheral blood could be considered a marker of favorable posttransplant clinical course. Occurence of HLA antibodies in recipients is also associated with elevated serum levels of CXCL8, CXCL10, CCL4, and CCL5.T. V. FedorenkoN. V. KolesnikovaI. A. PashkovaV. A. PorhanovE. A. GubarevaE. V. KuevdaSPb RAACIarticlekidney transplantationchemokinesallograft rejectiontransplantation immunitybiomarkerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 749-754 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	kidney transplantation chemokines allograft rejection transplantation immunity biomarker Immunologic diseases. Allergy RC581-607
spellingShingle	kidney transplantation chemokines allograft rejection transplantation immunity biomarker Immunologic diseases. Allergy RC581-607 T. V. Fedorenko N. V. Kolesnikova I. A. Pashkova V. A. Porhanov E. A. Gubareva E. V. Kuevda CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
description	It is known at the present time that immunological biomarkers may become more sensitive, non-invasive methods of graft rejection diagnosis than those currently used. A growing amount of studies in animal models shows that chemokines, as active participants in the immune process, may be used to this purpose. Our earlier studies have shown an important prognostic significance of IL-6, IL-2, 17A and IL-1RA increase in pre-operative period as markers of acute kidney allograft rejection. When assessing changes in studied peripheral blood growth factors, we concluded that a sharp decrease in BDNF content is a diagnostically significant early sign of kidney allograft rejection. The aim of this study was to identify the prognostic role of serum chemokine levels at the preoperative stage, taking into account the production of anti-HLA antibodies during the post-transplant period as a risk factor of kidney allograft rejection. A comparative analysis of chemokine serum concentrations was performed in the patients with terminal-stage chronic kidney disease (CKD). In the patients from main clinical groups, the blood cytokine levels were measured 6 hours before transplantation, i.e., Eotaxin (CCL11), GRO-α (CXCL1), IL-8 (CXCL8), IP-10 (CXCL10), MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4), SDF-1α (CXCL12), RANTES (CCL5), MIG (CXCL9) by means of multiplex immunological assays, using appropriate test systems. The studies have shown significant changes in several chemokines in the CKD patients compared to age-matched controls. However, the following diagnostically significant biomarkers associated with early rejection of transplanted kidney should be considered: increased concentration of CCL2 and CCL4 chemokines, as well as an acute decrease in CCL11. Significantly decreased CXCL12 concentration in peripheral blood could be considered a marker of favorable posttransplant clinical course. Occurence of HLA antibodies in recipients is also associated with elevated serum levels of CXCL8, CXCL10, CCL4, and CCL5.
format	article
author	T. V. Fedorenko N. V. Kolesnikova I. A. Pashkova V. A. Porhanov E. A. Gubareva E. V. Kuevda
author_facet	T. V. Fedorenko N. V. Kolesnikova I. A. Pashkova V. A. Porhanov E. A. Gubareva E. V. Kuevda
author_sort	T. V. Fedorenko
title	CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
title_short	CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
title_full	CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
title_fullStr	CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
title_full_unstemmed	CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT
title_sort	chemokine markers associated with early rejection of kidney allograft
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/c6710467511d4d46be502991979d5ced
work_keys_str_mv	AT tvfedorenko chemokinemarkersassociatedwithearlyrejectionofkidneyallograft AT nvkolesnikova chemokinemarkersassociatedwithearlyrejectionofkidneyallograft AT iapashkova chemokinemarkersassociatedwithearlyrejectionofkidneyallograft AT vaporhanov chemokinemarkersassociatedwithearlyrejectionofkidneyallograft AT eagubareva chemokinemarkersassociatedwithearlyrejectionofkidneyallograft AT evkuevda chemokinemarkersassociatedwithearlyrejectionofkidneyallograft
_version_	1718422380686082048

CHEMOKINE MARKERS ASSOCIATED WITH EARLY REJECTION OF KIDNEY ALLOGRAFT

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