Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

Double stranded DNA breaks are generated during rearrangements of lymphocyte antigen receptors. Here the authors show that the DNA breaks induce phosphorylation of nuclear GSK3β at Ser389/Thr390, protecting the activated lymphocytes from necroptosis-mediated cell death.

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Autores principales:	Tina M. Thornton, Pilar Delgado, Liang Chen, Beatriz Salas, Dimitry Krementsov, Miriam Fernandez, Santiago Vernia, Roger J. Davis, Ruth Heimann, Cory Teuscher, Michael S. Krangel, Almudena R. Ramiro, Mercedes Rincón
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6724a6232d643268dc7f38ec902b517
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spelling	oai:doaj.org-article:c6724a6232d643268dc7f38ec902b5172021-12-02T17:31:51ZInactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response10.1038/ncomms105532041-1723https://doaj.org/article/c6724a6232d643268dc7f38ec902b5172016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10553https://doaj.org/toc/2041-1723Double stranded DNA breaks are generated during rearrangements of lymphocyte antigen receptors. Here the authors show that the DNA breaks induce phosphorylation of nuclear GSK3β at Ser389/Thr390, protecting the activated lymphocytes from necroptosis-mediated cell death.Tina M. ThorntonPilar DelgadoLiang ChenBeatriz SalasDimitry KrementsovMiriam FernandezSantiago VerniaRoger J. DavisRuth HeimannCory TeuscherMichael S. KrangelAlmudena R. RamiroMercedes RincónNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tina M. Thornton Pilar Delgado Liang Chen Beatriz Salas Dimitry Krementsov Miriam Fernandez Santiago Vernia Roger J. Davis Ruth Heimann Cory Teuscher Michael S. Krangel Almudena R. Ramiro Mercedes Rincón Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
description	Double stranded DNA breaks are generated during rearrangements of lymphocyte antigen receptors. Here the authors show that the DNA breaks induce phosphorylation of nuclear GSK3β at Ser389/Thr390, protecting the activated lymphocytes from necroptosis-mediated cell death.
format	article
author	Tina M. Thornton Pilar Delgado Liang Chen Beatriz Salas Dimitry Krementsov Miriam Fernandez Santiago Vernia Roger J. Davis Ruth Heimann Cory Teuscher Michael S. Krangel Almudena R. Ramiro Mercedes Rincón
author_facet	Tina M. Thornton Pilar Delgado Liang Chen Beatriz Salas Dimitry Krementsov Miriam Fernandez Santiago Vernia Roger J. Davis Ruth Heimann Cory Teuscher Michael S. Krangel Almudena R. Ramiro Mercedes Rincón
author_sort	Tina M. Thornton
title	Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
title_short	Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
title_full	Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
title_fullStr	Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
title_full_unstemmed	Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
title_sort	inactivation of nuclear gsk3β by ser389 phosphorylation promotes lymphocyte fitness during dna double-strand break response
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c6724a6232d643268dc7f38ec902b517
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Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

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