Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance

Ioannis G Fatouros, Athanasios Z Jamurtas School of Physical Education and Sport Sciences, University of Thessaly, Karies, Trikala, Greece Abstract: The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also becaus...

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Autores principales:	Fatouros IG, Jamurtas AZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	muscle damage exercise aseptic inflammation recovery immune system redox status Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c675b13648ea47e0a389b1fc31d34fc2
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spelling	oai:doaj.org-article:c675b13648ea47e0a389b1fc31d34fc22021-12-02T02:26:53ZInsights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance1178-7031https://doaj.org/article/c675b13648ea47e0a389b1fc31d34fc22016-10-01T00:00:00Zhttps://www.dovepress.com/insights-into-the-molecular-etiology-of-exercise-induced-inflammation--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Ioannis G Fatouros, Athanasios Z Jamurtas School of Physical Education and Sport Sciences, University of Thessaly, Karies, Trikala, Greece Abstract: The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also because it is an excellent model to study the mechanisms governing muscle cachexia under various clinical conditions. Although, a large number of studies have investigated EIMD and its associated inflammatory response, several aspects of skeletal muscles responses remain unclear. In the first section of this article, the mechanisms of EIMD are reviewed in an attempt to follow the events that result in functional and structural alterations of skeletal muscle. In the second section, the inflammatory response associated with EIMD is presented with emphasis in leukocyte accumulation through mechanisms that are largely coordinated by pro- and anti-inflammatory cytokines released either by injured muscle itself or other cells. The practical applications of EIMD and the subsequent inflammatory response are discussed with respect to athletic performance. Specifically, the mechanisms leading to performance deterioration and development of muscle soreness are discussed. Emphasis is given to the factors affecting individual responses to EIMD and the resulting interindividual variability to this phenomenon. Keywords: muscle damage, exercise, aseptic inflammation, recovery, immune system, redox statusFatouros IGJamurtas AZDove Medical Pressarticlemuscle damageexerciseaseptic inflammationrecoveryimmune systemredox statusPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 9, Pp 175-186 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	muscle damage exercise aseptic inflammation recovery immune system redox status Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	muscle damage exercise aseptic inflammation recovery immune system redox status Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Fatouros IG Jamurtas AZ Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
description	Ioannis G Fatouros, Athanasios Z Jamurtas School of Physical Education and Sport Sciences, University of Thessaly, Karies, Trikala, Greece Abstract: The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also because it is an excellent model to study the mechanisms governing muscle cachexia under various clinical conditions. Although, a large number of studies have investigated EIMD and its associated inflammatory response, several aspects of skeletal muscles responses remain unclear. In the first section of this article, the mechanisms of EIMD are reviewed in an attempt to follow the events that result in functional and structural alterations of skeletal muscle. In the second section, the inflammatory response associated with EIMD is presented with emphasis in leukocyte accumulation through mechanisms that are largely coordinated by pro- and anti-inflammatory cytokines released either by injured muscle itself or other cells. The practical applications of EIMD and the subsequent inflammatory response are discussed with respect to athletic performance. Specifically, the mechanisms leading to performance deterioration and development of muscle soreness are discussed. Emphasis is given to the factors affecting individual responses to EIMD and the resulting interindividual variability to this phenomenon. Keywords: muscle damage, exercise, aseptic inflammation, recovery, immune system, redox status
format	article
author	Fatouros IG Jamurtas AZ
author_facet	Fatouros IG Jamurtas AZ
author_sort	Fatouros IG
title	Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
title_short	Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
title_full	Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
title_fullStr	Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
title_full_unstemmed	Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
title_sort	insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c675b13648ea47e0a389b1fc31d34fc2
work_keys_str_mv	AT fatourosig insightsintothemolecularetiologyofexerciseinducedinflammationopportunitiesforoptimizingperformance AT jamurtasaz insightsintothemolecularetiologyofexerciseinducedinflammationopportunitiesforoptimizingperformance
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Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance

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