The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>

ABSTRACT Historically, mucosal immunity—i.e., the portion of the immune system that protects an organism’s various mucous membranes from invasion by potentially pathogenic microbes—has been studied in single-cell epithelia in the gastrointestinal and upper respiratory tracts of vertebrates. Phylogen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katja Schröder, Thomas C. G. Bosch
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c67de1ae42614a26b30aa79039f891b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c67de1ae42614a26b30aa79039f891b2
record_format	dspace
spelling	oai:doaj.org-article:c67de1ae42614a26b30aa79039f891b22021-11-15T15:50:16ZThe Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>10.1128/mBio.01184-162150-7511https://doaj.org/article/c67de1ae42614a26b30aa79039f891b22016-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01184-16https://doaj.org/toc/2150-7511ABSTRACT Historically, mucosal immunity—i.e., the portion of the immune system that protects an organism’s various mucous membranes from invasion by potentially pathogenic microbes—has been studied in single-cell epithelia in the gastrointestinal and upper respiratory tracts of vertebrates. Phylogenetically, mucosal surfaces appeared for the first time about 560 million years ago in members of the phylum Cnidaria. There are remarkable similarities and shared functions of mucosal immunity in vertebrates and innate immunity in cnidarians, such as Hydra species. Here, we propose a common origin for both systems and review observations that indicate that the ultimately simple holobiont Hydra provides both a new perspective on the relationship between bacteria and animal cells and a new prism for viewing the emergence and evolution of epithelial tissue-based innate immunity. In addition, recent breakthroughs in our understanding of immune responses in Hydra polyps reared under defined short-term gnotobiotic conditions open up the potential of Hydra as an animal research model for the study of common mucosal disorders.Katja SchröderThomas C. G. BoschAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Katja Schröder Thomas C. G. Bosch The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>
description	ABSTRACT Historically, mucosal immunity—i.e., the portion of the immune system that protects an organism’s various mucous membranes from invasion by potentially pathogenic microbes—has been studied in single-cell epithelia in the gastrointestinal and upper respiratory tracts of vertebrates. Phylogenetically, mucosal surfaces appeared for the first time about 560 million years ago in members of the phylum Cnidaria. There are remarkable similarities and shared functions of mucosal immunity in vertebrates and innate immunity in cnidarians, such as Hydra species. Here, we propose a common origin for both systems and review observations that indicate that the ultimately simple holobiont Hydra provides both a new perspective on the relationship between bacteria and animal cells and a new prism for viewing the emergence and evolution of epithelial tissue-based innate immunity. In addition, recent breakthroughs in our understanding of immune responses in Hydra polyps reared under defined short-term gnotobiotic conditions open up the potential of Hydra as an animal research model for the study of common mucosal disorders.
format	article
author	Katja Schröder Thomas C. G. Bosch
author_facet	Katja Schröder Thomas C. G. Bosch
author_sort	Katja Schröder
title	The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>
title_short	The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>
title_full	The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>
title_fullStr	The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>
title_full_unstemmed	The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>
title_sort	origin of mucosal immunity: lessons from the holobiont <italic toggle="yes">hydra</italic>
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/c67de1ae42614a26b30aa79039f891b2
work_keys_str_mv	AT katjaschroder theoriginofmucosalimmunitylessonsfromtheholobiontitalictoggleyeshydraitalic AT thomascgbosch theoriginofmucosalimmunitylessonsfromtheholobiontitalictoggleyeshydraitalic AT katjaschroder originofmucosalimmunitylessonsfromtheholobiontitalictoggleyeshydraitalic AT thomascgbosch originofmucosalimmunitylessonsfromtheholobiontitalictoggleyeshydraitalic
_version_	1718427485234790400

The Origin of Mucosal Immunity: Lessons from the Holobiont <italic toggle="yes">Hydra</italic>

Ejemplares similares