Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis

Objectives While co‐morbid depression is associated with poor functional outcome among patients with schizophrenia, whether depression similarly predicts poorer outcomes in individuals at clinical high‐risk for psychosis (CHR‐P) is not clear. The present study aimed to examine depressive symptoms in...

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Autores principales:	Wisteria Deng, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker, Jutta Joormann, Tyrone Cannon
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/c681da59b66842aa8f43d6f5bad39c05
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spelling	oai:doaj.org-article:c681da59b66842aa8f43d6f5bad39c052021-12-02T13:52:49ZDepression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis2575-560910.1176/appi.prcp.20210023https://doaj.org/article/c681da59b66842aa8f43d6f5bad39c052021-12-01T00:00:00Zhttps://doi.org/10.1176/appi.prcp.20210023https://doaj.org/toc/2575-5609Objectives While co‐morbid depression is associated with poor functional outcome among patients with schizophrenia, whether depression similarly predicts poorer outcomes in individuals at clinical high‐risk for psychosis (CHR‐P) is not clear. The present study aimed to examine depressive symptoms in relation to long‐term global functional outcomes in the North American Prodrome Longitudinal Study cohort (NAPLS2). Methods CHR individuals were evaluated clinically at baseline and at 12‐ and 24‐month follow‐ups for depressive and prodromal symptom severity as well as general functioning. Regression models were built to investigate whether baseline positive and depressive symptom scores predicted longitudinal improvement in global functioning. Results A total of 406 CHR individuals completed the 12‐month follow‐up assessment and 259 CHR individuals completed the 24‐month assessment. Baseline depressive symptoms in the CHR‐P population were found to predict better global functional outcomes at 2 years. Furthermore, the degree of recovery of depressive symptoms in the first year following baseline completely mediated the association between depressive symptoms at baseline and functional improvement at 2 years. Conclusions Presence of affective symptoms within the CHR‐P population has different implications for prognosis compared with patients with schizophrenia. The present findings support the view that among those at risk for psychosis, depressive symptoms at baseline predict a more favorable course of functional recovery, and highlight the potential importance of treating co‐occurring depressive symptoms at an early stage of psychosis risk.Wisteria DengJean AddingtonCarrie E. BeardenKristin S. CadenheadBarbara A. CornblattDaniel H. MathalonThomas H. McGlashanDiana O. PerkinsLarry J. SeidmanMing T. TsuangScott W. WoodsElaine F. WalkerJutta JoormannTyrone CannonWileyarticlePsychiatryRC435-571ENPsychiatric Research and Clinical Practice, Vol 3, Iss 4, Pp 163-171 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Wisteria Deng Jean Addington Carrie E. Bearden Kristin S. Cadenhead Barbara A. Cornblatt Daniel H. Mathalon Thomas H. McGlashan Diana O. Perkins Larry J. Seidman Ming T. Tsuang Scott W. Woods Elaine F. Walker Jutta Joormann Tyrone Cannon Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
description	Objectives While co‐morbid depression is associated with poor functional outcome among patients with schizophrenia, whether depression similarly predicts poorer outcomes in individuals at clinical high‐risk for psychosis (CHR‐P) is not clear. The present study aimed to examine depressive symptoms in relation to long‐term global functional outcomes in the North American Prodrome Longitudinal Study cohort (NAPLS2). Methods CHR individuals were evaluated clinically at baseline and at 12‐ and 24‐month follow‐ups for depressive and prodromal symptom severity as well as general functioning. Regression models were built to investigate whether baseline positive and depressive symptom scores predicted longitudinal improvement in global functioning. Results A total of 406 CHR individuals completed the 12‐month follow‐up assessment and 259 CHR individuals completed the 24‐month assessment. Baseline depressive symptoms in the CHR‐P population were found to predict better global functional outcomes at 2 years. Furthermore, the degree of recovery of depressive symptoms in the first year following baseline completely mediated the association between depressive symptoms at baseline and functional improvement at 2 years. Conclusions Presence of affective symptoms within the CHR‐P population has different implications for prognosis compared with patients with schizophrenia. The present findings support the view that among those at risk for psychosis, depressive symptoms at baseline predict a more favorable course of functional recovery, and highlight the potential importance of treating co‐occurring depressive symptoms at an early stage of psychosis risk.
format	article
author	Wisteria Deng Jean Addington Carrie E. Bearden Kristin S. Cadenhead Barbara A. Cornblatt Daniel H. Mathalon Thomas H. McGlashan Diana O. Perkins Larry J. Seidman Ming T. Tsuang Scott W. Woods Elaine F. Walker Jutta Joormann Tyrone Cannon
author_facet	Wisteria Deng Jean Addington Carrie E. Bearden Kristin S. Cadenhead Barbara A. Cornblatt Daniel H. Mathalon Thomas H. McGlashan Diana O. Perkins Larry J. Seidman Ming T. Tsuang Scott W. Woods Elaine F. Walker Jutta Joormann Tyrone Cannon
author_sort	Wisteria Deng
title	Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
title_short	Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
title_full	Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
title_fullStr	Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
title_full_unstemmed	Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
title_sort	depression predicts global functional outcomes in individuals at clinical high risk for psychosis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c681da59b66842aa8f43d6f5bad39c05
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Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis

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