Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms rema...

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Autores principales:	Ana Sofía Vallés, Francisco J. Barrantes
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autism spectrum disorder nicotinic receptor (nAChR) cholesterol acetylcholine receptor-cholesterol interactions perinatal period Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c681e5d264994ec8b3bb595ce6be2952
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spelling	oai:doaj.org-article:c681e5d264994ec8b3bb595ce6be29522021-11-05T16:51:47ZDysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder1662-509910.3389/fnmol.2021.744597https://doaj.org/article/c681e5d264994ec8b3bb595ce6be29522021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.744597/fullhttps://doaj.org/toc/1662-5099Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms remain unclear, as are the factors that trigger their onset. Given the complexity and heterogeneity of the clinical phenotypes, a constellation of genetic, epigenetic, environmental, and immunological factors may be involved. The lack of appropriate biomarkers for the evaluation of neurodevelopmental disorders makes it difficult to assess the contribution of early alterations in neurochemical processes and neuroanatomical and neurodevelopmental factors to ASD. Abnormalities in the cholinergic system in various regions of the brain and cerebellum are observed in ASD, and recently altered cholesterol metabolism has been implicated at the initial stages of the disease. Given the multiple effects of the neutral lipid cholesterol on the paradigm rapid ligand-gated ion channel, the nicotinic acetylcholine receptor, we explore in this review the possibility that the dysregulation of nicotinic receptor-cholesterol crosstalk plays a role in some of the neurological alterations observed in ASD.Ana Sofía VallésFrancisco J. BarrantesFrontiers Media S.A.articleautism spectrum disordernicotinic receptor (nAChR)cholesterolacetylcholine receptor-cholesterol interactionsperinatal periodNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder nicotinic receptor (nAChR) cholesterol acetylcholine receptor-cholesterol interactions perinatal period Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism spectrum disorder nicotinic receptor (nAChR) cholesterol acetylcholine receptor-cholesterol interactions perinatal period Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ana Sofía Vallés Francisco J. Barrantes Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder
description	Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, and altered sensory processing. The underlying causes of the core symptoms remain unclear, as are the factors that trigger their onset. Given the complexity and heterogeneity of the clinical phenotypes, a constellation of genetic, epigenetic, environmental, and immunological factors may be involved. The lack of appropriate biomarkers for the evaluation of neurodevelopmental disorders makes it difficult to assess the contribution of early alterations in neurochemical processes and neuroanatomical and neurodevelopmental factors to ASD. Abnormalities in the cholinergic system in various regions of the brain and cerebellum are observed in ASD, and recently altered cholesterol metabolism has been implicated at the initial stages of the disease. Given the multiple effects of the neutral lipid cholesterol on the paradigm rapid ligand-gated ion channel, the nicotinic acetylcholine receptor, we explore in this review the possibility that the dysregulation of nicotinic receptor-cholesterol crosstalk plays a role in some of the neurological alterations observed in ASD.
format	article
author	Ana Sofía Vallés Francisco J. Barrantes
author_facet	Ana Sofía Vallés Francisco J. Barrantes
author_sort	Ana Sofía Vallés
title	Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder
title_short	Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder
title_full	Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder
title_fullStr	Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder
title_full_unstemmed	Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder
title_sort	dysregulation of neuronal nicotinic acetylcholine receptor–cholesterol crosstalk in autism spectrum disorder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c681e5d264994ec8b3bb595ce6be2952
work_keys_str_mv	AT anasofiavalles dysregulationofneuronalnicotinicacetylcholinereceptorcholesterolcrosstalkinautismspectrumdisorder AT franciscojbarrantes dysregulationofneuronalnicotinicacetylcholinereceptorcholesterolcrosstalkinautismspectrumdisorder
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Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder

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