Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

Chengqi Yan,1 Jing Chen,1 Xiaofan Yang,1 Wenqing Li,2 Renqun Mao,2 Zhenbing Chen1 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Hand and Foot Surgery, Huazhong Un...

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Autores principales:	Yan C, Chen J, Yang X, Li W, Mao R, Chen Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic foot ulcer long non-coding rnas diabetes mellitus wound healing Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c6844584e22f463baff928952d859145
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spelling	oai:doaj.org-article:c6844584e22f463baff928952d8591452021-12-02T17:37:20ZEmerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers1178-7007https://doaj.org/article/c6844584e22f463baff928952d8591452021-06-01T00:00:00Zhttps://www.dovepress.com/emerging-roles-of-long-non-coding-rnas-in-diabetic-foot-ulcers-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Chengqi Yan,1 Jing Chen,1 Xiaofan Yang,1 Wenqing Li,2 Renqun Mao,2 Zhenbing Chen1 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Hand and Foot Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of ChinaCorrespondence: Zhenbing ChenDepartment of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaTel +86 13871103730Fax +86 2785351628Email zbchen@hust.edu.cnAbstract: Diabetes mellitus is one of the most widespread metabolic diseases in the world, and diabetic foot ulcer (DFU), as one of its chronic complications, not only causes a large amount of physiological and psychological pain to patients but also places a tremendous burden on the entire economy and society. Despite significant advances in knowledge on the mechanism and in the treatment of DFU, clinical practice is still not satisfactory, and our understanding of its cellular and molecular pathogenesis is far from complete. Fortunately, progress in studying the roles of long non-coding RNAs (lncRNAs), which play important regulatory roles in the expression of genes at multiple levels, suggests that we can apply them in the early diagnosis and potential targeted intervention of DFU. In this review, we briefly summarize the current knowledge regarding the functional roles and potential mechanisms of reported lncRNAs in regulating DFU.Keywords: diabetic foot ulcer, long non-coding RNAs, diabetes mellitus, wound healingYan CChen JYang XLi WMao RChen ZDove Medical Pressarticlediabetic foot ulcerlong non-coding rnasdiabetes mellituswound healingSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2549-2560 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic foot ulcer long non-coding rnas diabetes mellitus wound healing Specialties of internal medicine RC581-951
spellingShingle	diabetic foot ulcer long non-coding rnas diabetes mellitus wound healing Specialties of internal medicine RC581-951 Yan C Chen J Yang X Li W Mao R Chen Z Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
description	Chengqi Yan,1 Jing Chen,1 Xiaofan Yang,1 Wenqing Li,2 Renqun Mao,2 Zhenbing Chen1 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Hand and Foot Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of ChinaCorrespondence: Zhenbing ChenDepartment of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaTel +86 13871103730Fax +86 2785351628Email zbchen@hust.edu.cnAbstract: Diabetes mellitus is one of the most widespread metabolic diseases in the world, and diabetic foot ulcer (DFU), as one of its chronic complications, not only causes a large amount of physiological and psychological pain to patients but also places a tremendous burden on the entire economy and society. Despite significant advances in knowledge on the mechanism and in the treatment of DFU, clinical practice is still not satisfactory, and our understanding of its cellular and molecular pathogenesis is far from complete. Fortunately, progress in studying the roles of long non-coding RNAs (lncRNAs), which play important regulatory roles in the expression of genes at multiple levels, suggests that we can apply them in the early diagnosis and potential targeted intervention of DFU. In this review, we briefly summarize the current knowledge regarding the functional roles and potential mechanisms of reported lncRNAs in regulating DFU.Keywords: diabetic foot ulcer, long non-coding RNAs, diabetes mellitus, wound healing
format	article
author	Yan C Chen J Yang X Li W Mao R Chen Z
author_facet	Yan C Chen J Yang X Li W Mao R Chen Z
author_sort	Yan C
title	Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
title_short	Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
title_full	Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
title_fullStr	Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
title_full_unstemmed	Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
title_sort	emerging roles of long non-coding rnas in diabetic foot ulcers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c6844584e22f463baff928952d859145
work_keys_str_mv	AT yanc emergingrolesoflongnoncodingrnasindiabeticfootulcers AT chenj emergingrolesoflongnoncodingrnasindiabeticfootulcers AT yangx emergingrolesoflongnoncodingrnasindiabeticfootulcers AT liw emergingrolesoflongnoncodingrnasindiabeticfootulcers AT maor emergingrolesoflongnoncodingrnasindiabeticfootulcers AT chenz emergingrolesoflongnoncodingrnasindiabeticfootulcers
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Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

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