Capture and light-induced release of antibiotics by an azo dye polymer

Abstract The isomerisation of azo dyes can induce conformational changes which have potential applications in medicine and environmental protection. We developed an agar diffusion assay to test the capture and release of biologically active molecules from an azo electro-optic polymer, Poly (Disperse...

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Autores principales:	Stephen Atkins, Alysa Chueh, Taylor Barwell, Jean-Michel Nunzi, Laurent Seroude
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c68498d4f3674834a8cce7996b63be11
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spelling	oai:doaj.org-article:c68498d4f3674834a8cce7996b63be112021-12-02T16:23:09ZCapture and light-induced release of antibiotics by an azo dye polymer10.1038/s41598-020-60245-62045-2322https://doaj.org/article/c68498d4f3674834a8cce7996b63be112020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-60245-6https://doaj.org/toc/2045-2322Abstract The isomerisation of azo dyes can induce conformational changes which have potential applications in medicine and environmental protection. We developed an agar diffusion assay to test the capture and release of biologically active molecules from an azo electro-optic polymer, Poly (Disperse Red 1 methacrylate) (DR1/PMMA). The assay monitors the growth of bacteria placed in soft agar under a glass coverslip. Antibiotics can then be applied on the coverslip resulting in the clearance of the area under the coverslip due to growth inhibition. This assay demonstrates that DR1/PMMA is able to capture either tetracycline or ampicillin and the relative amount of DR1/PMMA required for capture was determined. Finally, the active antibiotics can be released from DR1/PMMA by exposure to green laser light. Exposure to white light from a torch or to heat does not release the antibiotic.Stephen AtkinsAlysa ChuehTaylor BarwellJean-Michel NunziLaurent SeroudeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephen Atkins Alysa Chueh Taylor Barwell Jean-Michel Nunzi Laurent Seroude Capture and light-induced release of antibiotics by an azo dye polymer
description	Abstract The isomerisation of azo dyes can induce conformational changes which have potential applications in medicine and environmental protection. We developed an agar diffusion assay to test the capture and release of biologically active molecules from an azo electro-optic polymer, Poly (Disperse Red 1 methacrylate) (DR1/PMMA). The assay monitors the growth of bacteria placed in soft agar under a glass coverslip. Antibiotics can then be applied on the coverslip resulting in the clearance of the area under the coverslip due to growth inhibition. This assay demonstrates that DR1/PMMA is able to capture either tetracycline or ampicillin and the relative amount of DR1/PMMA required for capture was determined. Finally, the active antibiotics can be released from DR1/PMMA by exposure to green laser light. Exposure to white light from a torch or to heat does not release the antibiotic.
format	article
author	Stephen Atkins Alysa Chueh Taylor Barwell Jean-Michel Nunzi Laurent Seroude
author_facet	Stephen Atkins Alysa Chueh Taylor Barwell Jean-Michel Nunzi Laurent Seroude
author_sort	Stephen Atkins
title	Capture and light-induced release of antibiotics by an azo dye polymer
title_short	Capture and light-induced release of antibiotics by an azo dye polymer
title_full	Capture and light-induced release of antibiotics by an azo dye polymer
title_fullStr	Capture and light-induced release of antibiotics by an azo dye polymer
title_full_unstemmed	Capture and light-induced release of antibiotics by an azo dye polymer
title_sort	capture and light-induced release of antibiotics by an azo dye polymer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c68498d4f3674834a8cce7996b63be11
work_keys_str_mv	AT stephenatkins captureandlightinducedreleaseofantibioticsbyanazodyepolymer AT alysachueh captureandlightinducedreleaseofantibioticsbyanazodyepolymer AT taylorbarwell captureandlightinducedreleaseofantibioticsbyanazodyepolymer AT jeanmichelnunzi captureandlightinducedreleaseofantibioticsbyanazodyepolymer AT laurentseroude captureandlightinducedreleaseofantibioticsbyanazodyepolymer
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Capture and light-induced release of antibiotics by an azo dye polymer

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