Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer

Abstract To evaluate the clinical impact of preoperative glycemic status upon oncological and functional outcomes after radical prostatectomy in patients with localized prostate cancer, we analyzed the data of 2664 subjects who underwent radical prostatectomy with preoperative measurement of hemoglo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hakmin Lee, Seok-Soo Byun, Sang Eun Lee, Sung Kyu Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c685970399da4047a7defa69a1b8fa65
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c685970399da4047a7defa69a1b8fa65
record_format	dspace
spelling	oai:doaj.org-article:c685970399da4047a7defa69a1b8fa652021-12-02T14:58:24ZImpact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer10.1038/s41598-021-91310-32045-2322https://doaj.org/article/c685970399da4047a7defa69a1b8fa652021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91310-3https://doaj.org/toc/2045-2322Abstract To evaluate the clinical impact of preoperative glycemic status upon oncological and functional outcomes after radical prostatectomy in patients with localized prostate cancer, we analyzed the data of 2664 subjects who underwent radical prostatectomy with preoperative measurement of hemoglobin A1c within 6 months before surgery. The possible association between high hemoglobin A1c (≥ 6.5 ng/dL) and oncological/functional outcomes was evaluated. Among all subjects, 449 (16.9%) were categorized as the high hemoglobin A1c group and 2215 (83.1%) as the low hemoglobin A1c group. High hemoglobin A1c was associated with worse pathological outcomes including extra-capsular extension (HR 1.277, 95% CI 1.000–1.630, p = 0.050) and positive surgical margin (HR 1.302, 95% CI 1.012–1.674, p = 0.040) in multi-variate regression tests. Kaplan–Meier analysis showed statistically shorter biochemical recurrence-free survival in the high hemoglobin A1c group (p < 0.001), and subsequent multivariate Cox proportional analyses revealed that high hemoglobin A1c is an independent predictor for shorter BCR-free survival (HR 1.135, 95% CI 1.016–1.267, p = 0.024). Moreover, the high hemoglobin A1c group showed a significantly longer incontinence-free survival than the low hemoglobin A1c group (p = 0.001), and high preoperative hemoglobin A1c was also an independent predictor for longer incontinence-free survival in multivariate Cox analyses (HR 0.929, 95% CI 0.879–0.981, p = 0.008). The high preoperative hemoglobin A1c level was independently associated with worse oncological outcomes and also with inferior recovery of urinary continence after radical prostatectomy.Hakmin LeeSeok-Soo ByunSang Eun LeeSung Kyu HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hakmin Lee Seok-Soo Byun Sang Eun Lee Sung Kyu Hong Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
description	Abstract To evaluate the clinical impact of preoperative glycemic status upon oncological and functional outcomes after radical prostatectomy in patients with localized prostate cancer, we analyzed the data of 2664 subjects who underwent radical prostatectomy with preoperative measurement of hemoglobin A1c within 6 months before surgery. The possible association between high hemoglobin A1c (≥ 6.5 ng/dL) and oncological/functional outcomes was evaluated. Among all subjects, 449 (16.9%) were categorized as the high hemoglobin A1c group and 2215 (83.1%) as the low hemoglobin A1c group. High hemoglobin A1c was associated with worse pathological outcomes including extra-capsular extension (HR 1.277, 95% CI 1.000–1.630, p = 0.050) and positive surgical margin (HR 1.302, 95% CI 1.012–1.674, p = 0.040) in multi-variate regression tests. Kaplan–Meier analysis showed statistically shorter biochemical recurrence-free survival in the high hemoglobin A1c group (p < 0.001), and subsequent multivariate Cox proportional analyses revealed that high hemoglobin A1c is an independent predictor for shorter BCR-free survival (HR 1.135, 95% CI 1.016–1.267, p = 0.024). Moreover, the high hemoglobin A1c group showed a significantly longer incontinence-free survival than the low hemoglobin A1c group (p = 0.001), and high preoperative hemoglobin A1c was also an independent predictor for longer incontinence-free survival in multivariate Cox analyses (HR 0.929, 95% CI 0.879–0.981, p = 0.008). The high preoperative hemoglobin A1c level was independently associated with worse oncological outcomes and also with inferior recovery of urinary continence after radical prostatectomy.
format	article
author	Hakmin Lee Seok-Soo Byun Sang Eun Lee Sung Kyu Hong
author_facet	Hakmin Lee Seok-Soo Byun Sang Eun Lee Sung Kyu Hong
author_sort	Hakmin Lee
title	Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
title_short	Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
title_full	Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
title_fullStr	Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
title_full_unstemmed	Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
title_sort	impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c685970399da4047a7defa69a1b8fa65
work_keys_str_mv	AT hakminlee impactofpoorglycemiccontroluponclinicaloutcomesafterradicalprostatectomyinlocalizedprostatecancer AT seoksoobyun impactofpoorglycemiccontroluponclinicaloutcomesafterradicalprostatectomyinlocalizedprostatecancer AT sangeunlee impactofpoorglycemiccontroluponclinicaloutcomesafterradicalprostatectomyinlocalizedprostatecancer AT sungkyuhong impactofpoorglycemiccontroluponclinicaloutcomesafterradicalprostatectomyinlocalizedprostatecancer
_version_	1718389289120694272

Impact of poor glycemic control upon clinical outcomes after radical prostatectomy in localized prostate cancer

Ejemplares similares