Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages

Human mutations in the NDE1 gene have been associated with cortical malformations and severe microcephaly. Here, the authors show in embryonic rat brains that NDE1-depleted neural progenitors arrest at three specific cell cycle stages before mitosis, resulting in a severe decrease in neurogenesis.

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Autores principales:	David J. Doobin, Shahrnaz Kemal, Tiago J. Dantas, Richard B. Vallee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c687288b476a44bbbdc01ae2166912dd
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spelling	oai:doaj.org-article:c687288b476a44bbbdc01ae2166912dd2021-12-02T14:39:15ZSevere NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages10.1038/ncomms125512041-1723https://doaj.org/article/c687288b476a44bbbdc01ae2166912dd2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12551https://doaj.org/toc/2041-1723Human mutations in the NDE1 gene have been associated with cortical malformations and severe microcephaly. Here, the authors show in embryonic rat brains that NDE1-depleted neural progenitors arrest at three specific cell cycle stages before mitosis, resulting in a severe decrease in neurogenesis.David J. DoobinShahrnaz KemalTiago J. DantasRichard B. ValleeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David J. Doobin Shahrnaz Kemal Tiago J. Dantas Richard B. Vallee Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
description	Human mutations in the NDE1 gene have been associated with cortical malformations and severe microcephaly. Here, the authors show in embryonic rat brains that NDE1-depleted neural progenitors arrest at three specific cell cycle stages before mitosis, resulting in a severe decrease in neurogenesis.
format	article
author	David J. Doobin Shahrnaz Kemal Tiago J. Dantas Richard B. Vallee
author_facet	David J. Doobin Shahrnaz Kemal Tiago J. Dantas Richard B. Vallee
author_sort	David J. Doobin
title	Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
title_short	Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
title_full	Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
title_fullStr	Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
title_full_unstemmed	Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
title_sort	severe nde1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c687288b476a44bbbdc01ae2166912dd
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Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages

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