Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages

Human mutations in the NDE1 gene have been associated with cortical malformations and severe microcephaly. Here, the authors show in embryonic rat brains that NDE1-depleted neural progenitors arrest at three specific cell cycle stages before mitosis, resulting in a severe decrease in neurogenesis.

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Autores principales: David J. Doobin, Shahrnaz Kemal, Tiago J. Dantas, Richard B. Vallee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c687288b476a44bbbdc01ae2166912dd
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