Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents

Abstract The reaction of gold reagents [HAuCl4•3H2O], [AuCl(tht)], or cyclometalated gold(III) precursor, [C^NAuCl2] with chiral ((R,R)-(-)-2,3-bis(t-butylmethylphosphino) quinoxaline) and non-chiral phosphine (1,2-Bis(diphenylphosphino)ethane, dppe) ligands lead to distorted Au(I), (1, 2, 4, 5) and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jong Hyun Kim, Evan Reeder, Sean Parkin, Samuel G. Awuah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c687d6da5dc54928aaad050c95cb7fde
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c687d6da5dc54928aaad050c95cb7fde
record_format	dspace
spelling	oai:doaj.org-article:c687d6da5dc54928aaad050c95cb7fde2021-12-02T15:08:20ZGold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents10.1038/s41598-019-48584-52045-2322https://doaj.org/article/c687d6da5dc54928aaad050c95cb7fde2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48584-5https://doaj.org/toc/2045-2322Abstract The reaction of gold reagents [HAuCl4•3H2O], [AuCl(tht)], or cyclometalated gold(III) precursor, [C^NAuCl2] with chiral ((R,R)-(-)-2,3-bis(t-butylmethylphosphino) quinoxaline) and non-chiral phosphine (1,2-Bis(diphenylphosphino)ethane, dppe) ligands lead to distorted Au(I), (1, 2, 4, 5) and novel cyclometalated Au(III) complexes (3, 6). These gold compounds were characterized by multinuclear NMR, microanalysis, mass spectrometry, and X-ray crystallography. The inherent electrochemical properties of the gold complexes were also studied by cyclic voltammetry and theoretical insight of the complexes was gained by density functional theory and TD-DFT calculations. The complexes effectively kill cancer cells with IC50 in the range of ~0.10–2.53 μΜ across K562, H460, and OVCAR8 cell lines. In addition, the retinal pigment epithelial cell line, RPE-Neo was used as a healthy cell line for comparison. Differential cellular uptake in cancer cells was observed for the compounds by measuring the intracellular accumulation of gold using ICP-OES. Furthermore, the compounds trigger early – late stage apoptosis through potential disruption of redox homeostasis. Complexes 1 and 3 induce predominant G1 cell cycle arrest. Results presented in this report suggest that stable gold-phosphine complexes with variable oxidation states hold promise in anticancer drug discovery and need further development.Jong Hyun KimEvan ReederSean ParkinSamuel G. AwuahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Hyun Kim Evan Reeder Sean Parkin Samuel G. Awuah Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents
description	Abstract The reaction of gold reagents [HAuCl4•3H2O], [AuCl(tht)], or cyclometalated gold(III) precursor, [C^NAuCl2] with chiral ((R,R)-(-)-2,3-bis(t-butylmethylphosphino) quinoxaline) and non-chiral phosphine (1,2-Bis(diphenylphosphino)ethane, dppe) ligands lead to distorted Au(I), (1, 2, 4, 5) and novel cyclometalated Au(III) complexes (3, 6). These gold compounds were characterized by multinuclear NMR, microanalysis, mass spectrometry, and X-ray crystallography. The inherent electrochemical properties of the gold complexes were also studied by cyclic voltammetry and theoretical insight of the complexes was gained by density functional theory and TD-DFT calculations. The complexes effectively kill cancer cells with IC50 in the range of ~0.10–2.53 μΜ across K562, H460, and OVCAR8 cell lines. In addition, the retinal pigment epithelial cell line, RPE-Neo was used as a healthy cell line for comparison. Differential cellular uptake in cancer cells was observed for the compounds by measuring the intracellular accumulation of gold using ICP-OES. Furthermore, the compounds trigger early – late stage apoptosis through potential disruption of redox homeostasis. Complexes 1 and 3 induce predominant G1 cell cycle arrest. Results presented in this report suggest that stable gold-phosphine complexes with variable oxidation states hold promise in anticancer drug discovery and need further development.
format	article
author	Jong Hyun Kim Evan Reeder Sean Parkin Samuel G. Awuah
author_facet	Jong Hyun Kim Evan Reeder Sean Parkin Samuel G. Awuah
author_sort	Jong Hyun Kim
title	Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents
title_short	Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents
title_full	Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents
title_fullStr	Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents
title_full_unstemmed	Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents
title_sort	gold(i/iii)-phosphine complexes as potent antiproliferative agents
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c687d6da5dc54928aaad050c95cb7fde
work_keys_str_mv	AT jonghyunkim goldiiiiphosphinecomplexesaspotentantiproliferativeagents AT evanreeder goldiiiiphosphinecomplexesaspotentantiproliferativeagents AT seanparkin goldiiiiphosphinecomplexesaspotentantiproliferativeagents AT samuelgawuah goldiiiiphosphinecomplexesaspotentantiproliferativeagents
_version_	1718388213494579200

Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents

Ejemplares similares