Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat

Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat

Abstract Deterioration in glucose homeostasis has been associated with intestinal dysbiosis, but it is not known how metabolic dysregulation alters the gastrointestinal environment. We investigated how the progression of diabetes alters ileal and colonic epithelial mucosal structure, microbial abund...

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Main Authors: Brian D. Piccolo, James L. Graham, Ping Kang, Christopher E. Randolph, Kartik Shankar, Laxmi Yeruva, Renee Fox, Michael S. Robeson, Becky Moody, Tanya LeRoith, Kimber L. Stanhope, Sean H. Adams, Peter J. Havel
Format: article
Language:EN
Published: Wiley 2021
Subjects:
crypt
diabetes
microbiome
RNA‐seq
UCD‐T2DM rat
villi
Physiology
QP1-981
Online Access:https://doaj.org/article/c68b4547c4934ed29e8abdfeca5bbe3f
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