BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.

The specification of primordial germ cells (PGCs) and subsequent maintenance of germ-line identity in Drosophila embryos has long been thought to occur solely under the control of cell-autonomous factors deposited in the posterior pole plasm during oogenesis. However, here we document a novel role f...

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Autores principales:	Girish Deshpande, Elinor Willis, Sandip Chatterjee, Robert Fernandez, Kristen Dias, Paul Schedl
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c68e3406f8c941b8a413e25007c72e06
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spelling	oai:doaj.org-article:c68e3406f8c941b8a413e25007c72e062021-11-18T08:32:25ZBMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.1932-620310.1371/journal.pone.0088847https://doaj.org/article/c68e3406f8c941b8a413e25007c72e062014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24551179/?tool=EBIhttps://doaj.org/toc/1932-6203The specification of primordial germ cells (PGCs) and subsequent maintenance of germ-line identity in Drosophila embryos has long been thought to occur solely under the control of cell-autonomous factors deposited in the posterior pole plasm during oogenesis. However, here we document a novel role for somatic BMP signaling in the maintenance of PGC fate during the period leading up to embryonic gonad coalescence. We find that PGCs fail to maintain their germline identity when BMP signaling is compromised. They initiate but are unable to properly assemble the germline stem cell-specific organelle, the spectrosome, and they lose expression of the germline-specific gene Vasa. BMP signaling must, however, be finely tuned as there are deleterious consequences to PGCs when the pathway is excessively active. We show that one mechanism used to calibrate the effects of BMP signals is dependent on the Ubc9 homolog Lesswright (Lwr).Girish DeshpandeElinor WillisSandip ChatterjeeRobert FernandezKristen DiasPaul SchedlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88847 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Girish Deshpande Elinor Willis Sandip Chatterjee Robert Fernandez Kristen Dias Paul Schedl BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.
description	The specification of primordial germ cells (PGCs) and subsequent maintenance of germ-line identity in Drosophila embryos has long been thought to occur solely under the control of cell-autonomous factors deposited in the posterior pole plasm during oogenesis. However, here we document a novel role for somatic BMP signaling in the maintenance of PGC fate during the period leading up to embryonic gonad coalescence. We find that PGCs fail to maintain their germline identity when BMP signaling is compromised. They initiate but are unable to properly assemble the germline stem cell-specific organelle, the spectrosome, and they lose expression of the germline-specific gene Vasa. BMP signaling must, however, be finely tuned as there are deleterious consequences to PGCs when the pathway is excessively active. We show that one mechanism used to calibrate the effects of BMP signals is dependent on the Ubc9 homolog Lesswright (Lwr).
format	article
author	Girish Deshpande Elinor Willis Sandip Chatterjee Robert Fernandez Kristen Dias Paul Schedl
author_facet	Girish Deshpande Elinor Willis Sandip Chatterjee Robert Fernandez Kristen Dias Paul Schedl
author_sort	Girish Deshpande
title	BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.
title_short	BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.
title_full	BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.
title_fullStr	BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.
title_full_unstemmed	BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.
title_sort	bmp signaling and the maintenance of primordial germ cell identity in drosophila embryos.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c68e3406f8c941b8a413e25007c72e06
work_keys_str_mv	AT girishdeshpande bmpsignalingandthemaintenanceofprimordialgermcellidentityindrosophilaembryos AT elinorwillis bmpsignalingandthemaintenanceofprimordialgermcellidentityindrosophilaembryos AT sandipchatterjee bmpsignalingandthemaintenanceofprimordialgermcellidentityindrosophilaembryos AT robertfernandez bmpsignalingandthemaintenanceofprimordialgermcellidentityindrosophilaembryos AT kristendias bmpsignalingandthemaintenanceofprimordialgermcellidentityindrosophilaembryos AT paulschedl bmpsignalingandthemaintenanceofprimordialgermcellidentityindrosophilaembryos
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BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.

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