Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)

Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this disease and the high cost of its treatment, frequent drug resistance, different response to the drug, the possibility of using reliable methods to assess the control of seizures and side effects of antiepileptic dr...

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Autores principales:	Beata Smolarz, Marianna Makowska, Hanna Romanowicz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pharmacogenetics drug-resistant epilepsy genes CYP2 family MDR-1 GABA receptors Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c68f30162e31451aa5392754ce9032a4
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spelling	oai:doaj.org-article:c68f30162e31451aa5392754ce9032a42021-11-11T17:09:22ZPharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)10.3390/ijms2221116961422-00671661-6596https://doaj.org/article/c68f30162e31451aa5392754ce9032a42021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11696https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this disease and the high cost of its treatment, frequent drug resistance, different response to the drug, the possibility of using reliable methods to assess the control of seizures and side effects of antiepileptic drugs. Candidate genes encode proteins involved in pharmacokinetic processes (drug transporters, metabolizing enzymes), pharmacodynamic processes (receptors, ion channels, enzymes, regulatory proteins, secondary messengers) and drug hypersensitivity (immune factors). This article provides an overview of the literature on the influence of genetic factors on treatment in epilepsy.Beata SmolarzMarianna MakowskaHanna RomanowiczMDPI AGarticlepharmacogeneticsdrug-resistant epilepsygenesCYP2 familyMDR-1GABA receptorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11696, p 11696 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pharmacogenetics drug-resistant epilepsy genes CYP2 family MDR-1 GABA receptors Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	pharmacogenetics drug-resistant epilepsy genes CYP2 family MDR-1 GABA receptors Biology (General) QH301-705.5 Chemistry QD1-999 Beata Smolarz Marianna Makowska Hanna Romanowicz Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
description	Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this disease and the high cost of its treatment, frequent drug resistance, different response to the drug, the possibility of using reliable methods to assess the control of seizures and side effects of antiepileptic drugs. Candidate genes encode proteins involved in pharmacokinetic processes (drug transporters, metabolizing enzymes), pharmacodynamic processes (receptors, ion channels, enzymes, regulatory proteins, secondary messengers) and drug hypersensitivity (immune factors). This article provides an overview of the literature on the influence of genetic factors on treatment in epilepsy.
format	article
author	Beata Smolarz Marianna Makowska Hanna Romanowicz
author_facet	Beata Smolarz Marianna Makowska Hanna Romanowicz
author_sort	Beata Smolarz
title	Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
title_short	Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
title_full	Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
title_fullStr	Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
title_full_unstemmed	Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
title_sort	pharmacogenetics of drug-resistant epilepsy (review of literature)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c68f30162e31451aa5392754ce9032a4
work_keys_str_mv	AT beatasmolarz pharmacogeneticsofdrugresistantepilepsyreviewofliterature AT mariannamakowska pharmacogeneticsofdrugresistantepilepsyreviewofliterature AT hannaromanowicz pharmacogeneticsofdrugresistantepilepsyreviewofliterature
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Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)

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