Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

Extracellular vesicles (EVs) containing miRNAs or proteins can coordinate metabolic responses between tissues. Here the authors demonstrate that during lipid overload, the liver secretes miRNA-containing EVs through a Ggpps-Rab27 dependent mechanism, which controls adipose tissue lipid storage capac...

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Autores principales:	Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang, Xi-Tai Sun, Bin Xue, Chao-Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c690879c6ccc460ba0a45d4204010083
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spelling	oai:doaj.org-article:c690879c6ccc460ba0a45d42040100832021-12-02T14:40:39ZLiver governs adipose remodelling via extracellular vesicles in response to lipid overload10.1038/s41467-020-14450-62041-1723https://doaj.org/article/c690879c6ccc460ba0a45d42040100832020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14450-6https://doaj.org/toc/2041-1723Extracellular vesicles (EVs) containing miRNAs or proteins can coordinate metabolic responses between tissues. Here the authors demonstrate that during lipid overload, the liver secretes miRNA-containing EVs through a Ggpps-Rab27 dependent mechanism, which controls adipose tissue lipid storage capacity.Yue ZhaoMeng-Fei ZhaoShan JiangJing WuJia LiuXian-Wen YuanDi ShenJing-Zi ZhangNan ZhouJian HeLei FangXi-Tai SunBin XueChao-Jun LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue Zhao Meng-Fei Zhao Shan Jiang Jing Wu Jia Liu Xian-Wen Yuan Di Shen Jing-Zi Zhang Nan Zhou Jian He Lei Fang Xi-Tai Sun Bin Xue Chao-Jun Li Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
description	Extracellular vesicles (EVs) containing miRNAs or proteins can coordinate metabolic responses between tissues. Here the authors demonstrate that during lipid overload, the liver secretes miRNA-containing EVs through a Ggpps-Rab27 dependent mechanism, which controls adipose tissue lipid storage capacity.
format	article
author	Yue Zhao Meng-Fei Zhao Shan Jiang Jing Wu Jia Liu Xian-Wen Yuan Di Shen Jing-Zi Zhang Nan Zhou Jian He Lei Fang Xi-Tai Sun Bin Xue Chao-Jun Li
author_facet	Yue Zhao Meng-Fei Zhao Shan Jiang Jing Wu Jia Liu Xian-Wen Yuan Di Shen Jing-Zi Zhang Nan Zhou Jian He Lei Fang Xi-Tai Sun Bin Xue Chao-Jun Li
author_sort	Yue Zhao
title	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
title_short	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
title_full	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
title_fullStr	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
title_full_unstemmed	Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
title_sort	liver governs adipose remodelling via extracellular vesicles in response to lipid overload
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c690879c6ccc460ba0a45d4204010083
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Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

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