Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients

Ruoran Wang,1 Jing Zhang,1 Jing Xu,2 Min He,2 Jianguo Xu1 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 2Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s R...

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Autores principales:	Wang R, Zhang J, Xu J, He M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	acute kidney injury duration acute kidney injury burden traumatic brain injury mortality Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/c6938cb61b2e4a02b03b373056b74397
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spelling	oai:doaj.org-article:c6938cb61b2e4a02b03b373056b743972021-11-11T18:22:26ZIncidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients1179-1594https://doaj.org/article/c6938cb61b2e4a02b03b373056b743972021-11-01T00:00:00Zhttps://www.dovepress.com/incidence-and-burden-of-acute-kidney-injury-among-traumatic-brain-inju-peer-reviewed-fulltext-article-RMHPhttps://doaj.org/toc/1179-1594Ruoran Wang,1 Jing Zhang,1 Jing Xu,2 Min He,2 Jianguo Xu1 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 2Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of ChinaCorrespondence: Min HeDepartment of Critical Care Medicine, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, People’s Republic of ChinaEmail hemin19910306@wchscu.cnJianguo XuDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, People’s Republic of ChinaEmail xujg@scu.edu.cnBackground: Acute kidney injury (AKI) has been occurs commonly in the clinical management of traumatic brain injury (TBI) patients and is correlated with outcomes in these patients. We designed this study to investigate the incidence, duration, stage, and burden of AKI among these patients.Methods: A total of 419 TBI inpatients at our hospital were included in the study. We calculated the AKI burden, reflecting both stage and duration, and then analyzed associations among AKI occurrence, highest AKI stage, AKI duration, AKI burden, and outcomes with logistic regression analysis.Results: Incidence of AKI among TBI patients was 19.8%. These patients’ AKIs occurred mainly on the first day from admission (10.74%), and mostly developed stage 1 AKI (9.79%). Modes of AKI duration and burden in those with AKI were both 1. Multivariate logistic regression showed AKI occurrence (OR 3.792, p=0.004) and the highest AKI stage (OR 3.122, p< 0.001) was significantly associated with mortality. Neither AKI duration (OR 1.083, p=0.206) nor AKI burden (OR 1.062, p=0.171) were associated with mortality. Incorporating AKI occurrence or highest AKI stage did not improve the predictive value of the constructed prognostic model.Conclusion: The high-incidence period of AKI in TBI patients was the first 3 days after admission. AKI occurrence and highest AKI stage were associated with mortality, while AKI duration and AKI burden were not associated with mortality.Keywords: acute kidney-injury duration, acute kidney-injury burden, traumatic brain injury, mortalityWang RZhang JXu JHe MXu JDove Medical Pressarticleacute kidney injury durationacute kidney injury burdentraumatic brain injurymortalityPublic aspects of medicineRA1-1270ENRisk Management and Healthcare Policy, Vol Volume 14, Pp 4571-4580 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute kidney injury duration acute kidney injury burden traumatic brain injury mortality Public aspects of medicine RA1-1270
spellingShingle	acute kidney injury duration acute kidney injury burden traumatic brain injury mortality Public aspects of medicine RA1-1270 Wang R Zhang J Xu J He M Xu J Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients
description	Ruoran Wang,1 Jing Zhang,1 Jing Xu,2 Min He,2 Jianguo Xu1 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China; 2Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of ChinaCorrespondence: Min HeDepartment of Critical Care Medicine, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, People’s Republic of ChinaEmail hemin19910306@wchscu.cnJianguo XuDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, People’s Republic of ChinaEmail xujg@scu.edu.cnBackground: Acute kidney injury (AKI) has been occurs commonly in the clinical management of traumatic brain injury (TBI) patients and is correlated with outcomes in these patients. We designed this study to investigate the incidence, duration, stage, and burden of AKI among these patients.Methods: A total of 419 TBI inpatients at our hospital were included in the study. We calculated the AKI burden, reflecting both stage and duration, and then analyzed associations among AKI occurrence, highest AKI stage, AKI duration, AKI burden, and outcomes with logistic regression analysis.Results: Incidence of AKI among TBI patients was 19.8%. These patients’ AKIs occurred mainly on the first day from admission (10.74%), and mostly developed stage 1 AKI (9.79%). Modes of AKI duration and burden in those with AKI were both 1. Multivariate logistic regression showed AKI occurrence (OR 3.792, p=0.004) and the highest AKI stage (OR 3.122, p< 0.001) was significantly associated with mortality. Neither AKI duration (OR 1.083, p=0.206) nor AKI burden (OR 1.062, p=0.171) were associated with mortality. Incorporating AKI occurrence or highest AKI stage did not improve the predictive value of the constructed prognostic model.Conclusion: The high-incidence period of AKI in TBI patients was the first 3 days after admission. AKI occurrence and highest AKI stage were associated with mortality, while AKI duration and AKI burden were not associated with mortality.Keywords: acute kidney-injury duration, acute kidney-injury burden, traumatic brain injury, mortality
format	article
author	Wang R Zhang J Xu J He M Xu J
author_facet	Wang R Zhang J Xu J He M Xu J
author_sort	Wang R
title	Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients
title_short	Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients
title_full	Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients
title_fullStr	Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients
title_full_unstemmed	Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients
title_sort	incidence and burden of acute kidney injury among traumatic brain-injury patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c6938cb61b2e4a02b03b373056b74397
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Incidence and Burden of Acute Kidney Injury among Traumatic Brain-Injury Patients

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