FoxO1-mediated autophagy is required for NK cell development and innate immunity

Natural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species.

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Autores principales:	Shuo Wang, Pengyan Xia, Guanling Huang, Pingping Zhu, Jing Liu, Buqing Ye, Ying Du, Zusen Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c697bebcc1d3445d9375a769a48af964
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spelling	oai:doaj.org-article:c697bebcc1d3445d9375a769a48af9642021-12-02T16:49:59ZFoxO1-mediated autophagy is required for NK cell development and innate immunity10.1038/ncomms110232041-1723https://doaj.org/article/c697bebcc1d3445d9375a769a48af9642016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11023https://doaj.org/toc/2041-1723Natural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species.Shuo WangPengyan XiaGuanling HuangPingping ZhuJing LiuBuqing YeYing DuZusen FanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuo Wang Pengyan Xia Guanling Huang Pingping Zhu Jing Liu Buqing Ye Ying Du Zusen Fan FoxO1-mediated autophagy is required for NK cell development and innate immunity
description	Natural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species.
format	article
author	Shuo Wang Pengyan Xia Guanling Huang Pingping Zhu Jing Liu Buqing Ye Ying Du Zusen Fan
author_facet	Shuo Wang Pengyan Xia Guanling Huang Pingping Zhu Jing Liu Buqing Ye Ying Du Zusen Fan
author_sort	Shuo Wang
title	FoxO1-mediated autophagy is required for NK cell development and innate immunity
title_short	FoxO1-mediated autophagy is required for NK cell development and innate immunity
title_full	FoxO1-mediated autophagy is required for NK cell development and innate immunity
title_fullStr	FoxO1-mediated autophagy is required for NK cell development and innate immunity
title_full_unstemmed	FoxO1-mediated autophagy is required for NK cell development and innate immunity
title_sort	foxo1-mediated autophagy is required for nk cell development and innate immunity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c697bebcc1d3445d9375a769a48af964
work_keys_str_mv	AT shuowang foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT pengyanxia foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT guanlinghuang foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT pingpingzhu foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT jingliu foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT buqingye foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT yingdu foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity AT zusenfan foxo1mediatedautophagyisrequiredfornkcelldevelopmentandinnateimmunity
_version_	1718383183451389952

FoxO1-mediated autophagy is required for NK cell development and innate immunity

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