Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin

The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis. We conducted a systematic review and meta-analysis of the effects of statins on the circulating cell adhesion molecules E-Select...

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Autores principales:	Angelo Zinellu, Arduino A. Mangoni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	statins E-Selectin L-Selectin P-Selectin atherosclerosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c69c7a09393a49c4ab6744e96af6549b
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spelling	oai:doaj.org-article:c69c7a09393a49c4ab6744e96af6549b2021-11-25T16:51:04ZSystematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin10.3390/biomedicines91117072227-9059https://doaj.org/article/c69c7a09393a49c4ab6744e96af6549b2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1707https://doaj.org/toc/2227-9059The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis. We conducted a systematic review and meta-analysis of the effects of statins on the circulating cell adhesion molecules E-Selectin, L-Selectin, and P-Selectin. A literature search was conducted in PubMed, Web of Science, and Scopus, from inception to July 2021. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and GRADE, respectively. In 61 studies, statins significantly reduced P-selectin (standard mean difference, SMD = −0.39, 95% CI −0.55 to −0.22, <i>p</i> < 0.001; moderate certainty of evidence), L-selectin (SMD = −0.49, 95% CI −0.89 to −0.10, <i>p</i> = 0.014; very low certainty of evidence), and E-Selectin (SMD = −0.73, 95% CI −1.02 to −0.43, <i>p</i> < 0.001; moderate certainty of evidence), independently of baseline lipid profile and other study and patient characteristics. The corresponding pooled SMD values in sensitivity analysis were not substantially altered when individual studies were sequentially removed. Simvastatin had a significant lowering effect on both P-selectin and E-selectin. Therefore, statins significantly reduce circulating selectins. Further studies are required to investigate whether selectin lowering mediates cardiovascular risk reduction with these agents. (PROSPERO registration number: CRD42021282778).Angelo ZinelluArduino A. MangoniMDPI AGarticlestatinsE-SelectinL-SelectinP-SelectinatherosclerosisBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1707, p 1707 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	statins E-Selectin L-Selectin P-Selectin atherosclerosis Biology (General) QH301-705.5
spellingShingle	statins E-Selectin L-Selectin P-Selectin atherosclerosis Biology (General) QH301-705.5 Angelo Zinellu Arduino A. Mangoni Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
description	The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis. We conducted a systematic review and meta-analysis of the effects of statins on the circulating cell adhesion molecules E-Selectin, L-Selectin, and P-Selectin. A literature search was conducted in PubMed, Web of Science, and Scopus, from inception to July 2021. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and GRADE, respectively. In 61 studies, statins significantly reduced P-selectin (standard mean difference, SMD = −0.39, 95% CI −0.55 to −0.22, <i>p</i> < 0.001; moderate certainty of evidence), L-selectin (SMD = −0.49, 95% CI −0.89 to −0.10, <i>p</i> = 0.014; very low certainty of evidence), and E-Selectin (SMD = −0.73, 95% CI −1.02 to −0.43, <i>p</i> < 0.001; moderate certainty of evidence), independently of baseline lipid profile and other study and patient characteristics. The corresponding pooled SMD values in sensitivity analysis were not substantially altered when individual studies were sequentially removed. Simvastatin had a significant lowering effect on both P-selectin and E-selectin. Therefore, statins significantly reduce circulating selectins. Further studies are required to investigate whether selectin lowering mediates cardiovascular risk reduction with these agents. (PROSPERO registration number: CRD42021282778).
format	article
author	Angelo Zinellu Arduino A. Mangoni
author_facet	Angelo Zinellu Arduino A. Mangoni
author_sort	Angelo Zinellu
title	Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
title_short	Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
title_full	Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
title_fullStr	Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
title_full_unstemmed	Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
title_sort	systematic review and meta-analysis of the effect of statins on circulating e-selectin, l-selectin, and p-selectin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c69c7a09393a49c4ab6744e96af6549b
work_keys_str_mv	AT angelozinellu systematicreviewandmetaanalysisoftheeffectofstatinsoncirculatingeselectinlselectinandpselectin AT arduinoamangoni systematicreviewandmetaanalysisoftheeffectofstatinsoncirculatingeselectinlselectinandpselectin
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Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin

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