Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia

Belete Biadgo,1 Mulugeta Melku,2 Solomon Mekonnen Abebe,3 Molla Abebe1 1School of Biomedical and Laboratory Sciences, Department of Clinical Chemistry, 2School of Biomedical and Laboratory Sciences, Department of Hematology and Immunohematology, 3Institute of Public Health, College of Medicine and H...

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Autores principales:	Biadgo B, Melku M, Abebe SM, Abebe M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Ethiopia fasting blood glucose Gondar hematological indices Type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c6a85add16794e9285b9f454280e5a96
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spelling	oai:doaj.org-article:c6a85add16794e9285b9f454280e5a962021-12-02T02:28:31ZHematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia1178-7007https://doaj.org/article/c6a85add16794e9285b9f454280e5a962016-03-01T00:00:00Zhttps://www.dovepress.com/hematological-indices-and-their-correlation-with-fasting-blood-glucose-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Belete Biadgo,1 Mulugeta Melku,2 Solomon Mekonnen Abebe,3 Molla Abebe1 1School of Biomedical and Laboratory Sciences, Department of Clinical Chemistry, 2School of Biomedical and Laboratory Sciences, Department of Hematology and Immunohematology, 3Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Background: Diabetes mellitus is (DM) a global public health problem and a complex disease characterized by chronic hyperglycemia that leads to long-term macrovascular and microvascular complications. Recent studies have reported the role of hematological indices in contributing to the vascular injury in diabetic patients. Thus, the aim of this study was to determine hematological indices and their correlation with fasting blood glucose level and anthropometric measurement in type 2 DM patients in comparison with healthy controls. Methods: A comparative cross-sectional study was conducted at the chronic illness clinic of Gondar University Hospital from February to April 2015. A total of 296 participants (148 cases and 148 healthy controls) were selected using systematic random sampling technique. Data were collected using a pretested structured questionnaire. Fasting blood glucose levels and hematological indices were determined by using Bio Systems A25 and Sysmex-KX 21N analyzers, respectively. Independent sample t-test, Mann–Whitney U-test, and correlation statistics were used. A P-value <0.05 was considered as statistically significant. Result: There was significant difference in red blood cell distribution width (47.3±2.6 fL vs 45.2±3 fL) between diabetic patients and controls. Total white blood cells in 103/µL (6.59±1.42 vs 5.56±1.38), absolute lymphocyte count in 103/µL (2.60±0.70 vs 2.04±0.63), and absolute neutrophil count in 103/µL (3.57±1.46 vs 3.11±1.04) increased significantly in diabetic patients compared with controls, respectively. Among platelet indices, mean platelet volume (10.4±1.1 fL vs 9.9±1.1 fL) and platelet distribution width (14.5±2.1 fL vs 13.4±2.1 fL) were found to be significantly increased in the diabetic patients (P<0.05). Anthropometric measurements significantly correlated with white blood cell and platelet indices. Conclusion: The study showed statistically significant difference in some hematological parameters of diabetic patients compared to controls. Thus, hematological indices could be useful indicators of vascular complication and glycemic control in type 2 DM patients. Keywords: Ethiopia, fasting blood glucose, Gondar, hematological indices, type 2 diabetes mellitusBiadgo BMelku MAbebe SMAbebe MDove Medical PressarticleEthiopiafasting blood glucoseGondarhematological indicesType 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 91-99 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ethiopia fasting blood glucose Gondar hematological indices Type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	Ethiopia fasting blood glucose Gondar hematological indices Type 2 diabetes mellitus Specialties of internal medicine RC581-951 Biadgo B Melku M Abebe SM Abebe M Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia
description	Belete Biadgo,1 Mulugeta Melku,2 Solomon Mekonnen Abebe,3 Molla Abebe1 1School of Biomedical and Laboratory Sciences, Department of Clinical Chemistry, 2School of Biomedical and Laboratory Sciences, Department of Hematology and Immunohematology, 3Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Background: Diabetes mellitus is (DM) a global public health problem and a complex disease characterized by chronic hyperglycemia that leads to long-term macrovascular and microvascular complications. Recent studies have reported the role of hematological indices in contributing to the vascular injury in diabetic patients. Thus, the aim of this study was to determine hematological indices and their correlation with fasting blood glucose level and anthropometric measurement in type 2 DM patients in comparison with healthy controls. Methods: A comparative cross-sectional study was conducted at the chronic illness clinic of Gondar University Hospital from February to April 2015. A total of 296 participants (148 cases and 148 healthy controls) were selected using systematic random sampling technique. Data were collected using a pretested structured questionnaire. Fasting blood glucose levels and hematological indices were determined by using Bio Systems A25 and Sysmex-KX 21N analyzers, respectively. Independent sample t-test, Mann–Whitney U-test, and correlation statistics were used. A P-value <0.05 was considered as statistically significant. Result: There was significant difference in red blood cell distribution width (47.3±2.6 fL vs 45.2±3 fL) between diabetic patients and controls. Total white blood cells in 103/µL (6.59±1.42 vs 5.56±1.38), absolute lymphocyte count in 103/µL (2.60±0.70 vs 2.04±0.63), and absolute neutrophil count in 103/µL (3.57±1.46 vs 3.11±1.04) increased significantly in diabetic patients compared with controls, respectively. Among platelet indices, mean platelet volume (10.4±1.1 fL vs 9.9±1.1 fL) and platelet distribution width (14.5±2.1 fL vs 13.4±2.1 fL) were found to be significantly increased in the diabetic patients (P<0.05). Anthropometric measurements significantly correlated with white blood cell and platelet indices. Conclusion: The study showed statistically significant difference in some hematological parameters of diabetic patients compared to controls. Thus, hematological indices could be useful indicators of vascular complication and glycemic control in type 2 DM patients. Keywords: Ethiopia, fasting blood glucose, Gondar, hematological indices, type 2 diabetes mellitus
format	article
author	Biadgo B Melku M Abebe SM Abebe M
author_facet	Biadgo B Melku M Abebe SM Abebe M
author_sort	Biadgo B
title	Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia
title_short	Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia
title_full	Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia
title_fullStr	Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia
title_full_unstemmed	Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia
title_sort	hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in gondar, northwest ethiopia
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c6a85add16794e9285b9f454280e5a96
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Hematological indices and their correlation with fasting blood glucose level and anthropometric measurements in type 2 diabetes mellitus patients in Gondar, Northwest Ethiopia

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