Phytotherapy in treatment of Parkinson’s disease: a review

Context: Parkinson’s disease (PD) is a neurodegenerative disorder due to gradual loss of dopaminergic nerves in the substantia nigra (SN) in the midbrain. PD leads to certain motor disorders including resting tremor, muscle stiffness and slow movement. Medicinal plants have shown positive pharmacolo...

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Autores principales:	Zahra Rabiei, Kamal Solati, Hossein Amini-Khoei
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	dopaminergic receptors l-dopa ginkgo biloba curcumin Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c6a8cecc17b64997a2ff748c6ebffd00
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spelling	oai:doaj.org-article:c6a8cecc17b64997a2ff748c6ebffd002021-11-17T14:21:56ZPhytotherapy in treatment of Parkinson’s disease: a review1388-02091744-511610.1080/13880209.2019.1618344https://doaj.org/article/c6a8cecc17b64997a2ff748c6ebffd002019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1618344https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Parkinson’s disease (PD) is a neurodegenerative disorder due to gradual loss of dopaminergic nerves in the substantia nigra (SN) in the midbrain. PD leads to certain motor disorders including resting tremor, muscle stiffness and slow movement. Medicinal plants have shown positive pharmacological effects in treating different models of PD. Objective: Tendency to use natural products, especially plants, for the treatment of PD has been growing. This article reviews the basic aspects of medicinal plants and their bioactive compounds that could be used to treat PD. Methods: Reliable articles indexed in databases ISI, SID, PubMed, PubMed Central, Scopus and Web of Science were used. A total of 12 plant-derived active ingredients and 18 herbal extracts were included. Different compounds have so far been isolated from plants that affect PD especially by targeting pathways associated with the pathogenesis of the disease. Results: Although some herbal extracts such as Hibiscus asper Hook. f. (Malvaceae), Ginkgo biloba L. (Ginkgoaceae), Carthamus tinctorius L (Asteraceae) and certain active ingredients, such as berberine and curcumin, have shown positive effects in animal models of PD, potential active ingredients and mechanisms of action should be investigated in additional studies. Discussion and conclusions: Despite the wide variety of plants in the world, a limited number of them have been studied for anti-Parkinsonian activity, and therefore, there are numerous perspectives in this field for future studies on plants and their bioactive compounds.Zahra RabieiKamal SolatiHossein Amini-KhoeiTaylor & Francis Grouparticledopaminergic receptorsl-dopaginkgo bilobacurcuminTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 355-362 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dopaminergic receptors l-dopa ginkgo biloba curcumin Therapeutics. Pharmacology RM1-950
spellingShingle	dopaminergic receptors l-dopa ginkgo biloba curcumin Therapeutics. Pharmacology RM1-950 Zahra Rabiei Kamal Solati Hossein Amini-Khoei Phytotherapy in treatment of Parkinson’s disease: a review
description	Context: Parkinson’s disease (PD) is a neurodegenerative disorder due to gradual loss of dopaminergic nerves in the substantia nigra (SN) in the midbrain. PD leads to certain motor disorders including resting tremor, muscle stiffness and slow movement. Medicinal plants have shown positive pharmacological effects in treating different models of PD. Objective: Tendency to use natural products, especially plants, for the treatment of PD has been growing. This article reviews the basic aspects of medicinal plants and their bioactive compounds that could be used to treat PD. Methods: Reliable articles indexed in databases ISI, SID, PubMed, PubMed Central, Scopus and Web of Science were used. A total of 12 plant-derived active ingredients and 18 herbal extracts were included. Different compounds have so far been isolated from plants that affect PD especially by targeting pathways associated with the pathogenesis of the disease. Results: Although some herbal extracts such as Hibiscus asper Hook. f. (Malvaceae), Ginkgo biloba L. (Ginkgoaceae), Carthamus tinctorius L (Asteraceae) and certain active ingredients, such as berberine and curcumin, have shown positive effects in animal models of PD, potential active ingredients and mechanisms of action should be investigated in additional studies. Discussion and conclusions: Despite the wide variety of plants in the world, a limited number of them have been studied for anti-Parkinsonian activity, and therefore, there are numerous perspectives in this field for future studies on plants and their bioactive compounds.
format	article
author	Zahra Rabiei Kamal Solati Hossein Amini-Khoei
author_facet	Zahra Rabiei Kamal Solati Hossein Amini-Khoei
author_sort	Zahra Rabiei
title	Phytotherapy in treatment of Parkinson’s disease: a review
title_short	Phytotherapy in treatment of Parkinson’s disease: a review
title_full	Phytotherapy in treatment of Parkinson’s disease: a review
title_fullStr	Phytotherapy in treatment of Parkinson’s disease: a review
title_full_unstemmed	Phytotherapy in treatment of Parkinson’s disease: a review
title_sort	phytotherapy in treatment of parkinson’s disease: a review
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/c6a8cecc17b64997a2ff748c6ebffd00
work_keys_str_mv	AT zahrarabiei phytotherapyintreatmentofparkinsonsdiseaseareview AT kamalsolati phytotherapyintreatmentofparkinsonsdiseaseareview AT hosseinaminikhoei phytotherapyintreatmentofparkinsonsdiseaseareview
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Phytotherapy in treatment of Parkinson’s disease: a review

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