Macrocytosis among patients with heroin use disorder

Mei-Hing Ng,1,2 Vincent Chin-Hung Chen,3,4 Hua Ting,1,5 Tsang-Yaw Lin,2 Sheng-Huang Chang,2 Michael Gossop61Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 2Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nan-Tou County, Taiwan; 3Department of Psychiatry, Chang Gu...

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Autores principales:	Ng MH, Chen VCH, Ting H, Lin TY, Chang SH, Gossop M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	addiction opioid dependence substitution treatment megalocytes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c6aceca892114ee5b92a34adbfcbd024
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spelling	oai:doaj.org-article:c6aceca892114ee5b92a34adbfcbd0242021-12-02T11:30:45ZMacrocytosis among patients with heroin use disorder1178-2021https://doaj.org/article/c6aceca892114ee5b92a34adbfcbd0242019-08-01T00:00:00Zhttps://www.dovepress.com/macrocytosis-among-patients-with-heroin-use-disorder-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mei-Hing Ng,1,2 Vincent Chin-Hung Chen,3,4 Hua Ting,1,5 Tsang-Yaw Lin,2 Sheng-Huang Chang,2 Michael Gossop61Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 2Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nan-Tou County, Taiwan; 3Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi County, Taiwan; 4Department of Psychiatry, School of Medicine, Chang Gung University, Taoyuan City, Taiwan; 5Department of Physical Medicine and Rehabilitation, Chung-Shan Medical, University Hospital, Chung-Shan Medical University, Taichung, Taiwan; 6National Addiction Center, Institute of Psychiatry, King’s College London, London, UKPurpose: Few empirical studies have investigated hematological parameters among people with a heroin use disorder. This study explores the prevalence of macrocytosis and associated factors among patients with heroin use disorder who were entering methadone maintenance treatment (MMT) in Taiwan.Patients and methods: In this cross-sectional study, hematological parameters were measured and the prevalence of macrocytosis was assessed in a sample of 958 patients with a heroin use disorder entering the MMT program at Tsaotun Psychiatric Center in Taiwan. The demographic characteristics, heroin-related issues, other substance use history, and other clinical variables were analyzed. Univariate analysis was used to assess the association of all variables. Multivariable logistic regression was used to identify the relationship between the significant factors and macrocytosis.Results: The study found that nearly one-fifth (19.5%) of the participants had macrocytosis. Older age, longer duration of heroin use, and more days of alcohol use within the previous month were associated with macrocytosis.Conclusion: We found that concurrent use of alcohol was an important factor related to macrocytosis among people with a heroin use disorder. The prevalence of macrocytosis indicated that alcohol use is common among this population. It is suggested that policies and practices regarding alcohol use should be addressed within methadone maintenance programs.Keywords: addiction, opioid dependence, substitution treatment, megalocytesNg MHChen VCHTing HLin TYChang SHGossop MDove Medical Pressarticleaddictionopioid dependencesubstitution treatmentmegalocytesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2293-2298 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	addiction opioid dependence substitution treatment megalocytes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	addiction opioid dependence substitution treatment megalocytes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ng MH Chen VCH Ting H Lin TY Chang SH Gossop M Macrocytosis among patients with heroin use disorder
description	Mei-Hing Ng,1,2 Vincent Chin-Hung Chen,3,4 Hua Ting,1,5 Tsang-Yaw Lin,2 Sheng-Huang Chang,2 Michael Gossop61Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 2Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nan-Tou County, Taiwan; 3Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi County, Taiwan; 4Department of Psychiatry, School of Medicine, Chang Gung University, Taoyuan City, Taiwan; 5Department of Physical Medicine and Rehabilitation, Chung-Shan Medical, University Hospital, Chung-Shan Medical University, Taichung, Taiwan; 6National Addiction Center, Institute of Psychiatry, King’s College London, London, UKPurpose: Few empirical studies have investigated hematological parameters among people with a heroin use disorder. This study explores the prevalence of macrocytosis and associated factors among patients with heroin use disorder who were entering methadone maintenance treatment (MMT) in Taiwan.Patients and methods: In this cross-sectional study, hematological parameters were measured and the prevalence of macrocytosis was assessed in a sample of 958 patients with a heroin use disorder entering the MMT program at Tsaotun Psychiatric Center in Taiwan. The demographic characteristics, heroin-related issues, other substance use history, and other clinical variables were analyzed. Univariate analysis was used to assess the association of all variables. Multivariable logistic regression was used to identify the relationship between the significant factors and macrocytosis.Results: The study found that nearly one-fifth (19.5%) of the participants had macrocytosis. Older age, longer duration of heroin use, and more days of alcohol use within the previous month were associated with macrocytosis.Conclusion: We found that concurrent use of alcohol was an important factor related to macrocytosis among people with a heroin use disorder. The prevalence of macrocytosis indicated that alcohol use is common among this population. It is suggested that policies and practices regarding alcohol use should be addressed within methadone maintenance programs.Keywords: addiction, opioid dependence, substitution treatment, megalocytes
format	article
author	Ng MH Chen VCH Ting H Lin TY Chang SH Gossop M
author_facet	Ng MH Chen VCH Ting H Lin TY Chang SH Gossop M
author_sort	Ng MH
title	Macrocytosis among patients with heroin use disorder
title_short	Macrocytosis among patients with heroin use disorder
title_full	Macrocytosis among patients with heroin use disorder
title_fullStr	Macrocytosis among patients with heroin use disorder
title_full_unstemmed	Macrocytosis among patients with heroin use disorder
title_sort	macrocytosis among patients with heroin use disorder
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c6aceca892114ee5b92a34adbfcbd024
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_version_	1718395903851626496

Macrocytosis among patients with heroin use disorder

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