Lipid Nanocarriers for Hyperproliferative Skin Diseases

Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are s...

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Autores principales:	Eliana B. Souto, Ana L. R. de Souza, Fernanda K. dos Santos, Elena Sanchez-Lopez, Amanda Cano, Aleksandra Zielińska, Rafał Staszewski, Jacek Karczewski, Maria P. D. Gremião, Marlus Chorilli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lipid nanoparticles liposomes hyperproliferative skin diseases antiproliferative drugs skin cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c6b1670306f6441f9db4e770188047d8
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spelling	oai:doaj.org-article:c6b1670306f6441f9db4e770188047d82021-11-25T17:01:41ZLipid Nanocarriers for Hyperproliferative Skin Diseases10.3390/cancers132256192072-6694https://doaj.org/article/c6b1670306f6441f9db4e770188047d82021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5619https://doaj.org/toc/2072-6694Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.Eliana B. SoutoAna L. R. de SouzaFernanda K. dos SantosElena Sanchez-LopezAmanda CanoAleksandra ZielińskaRafał StaszewskiJacek KarczewskiMaria P. D. GremiãoMarlus ChorilliMDPI AGarticlelipid nanoparticlesliposomeshyperproliferative skin diseasesantiproliferative drugsskin cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5619, p 5619 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid nanoparticles liposomes hyperproliferative skin diseases antiproliferative drugs skin cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lipid nanoparticles liposomes hyperproliferative skin diseases antiproliferative drugs skin cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Eliana B. Souto Ana L. R. de Souza Fernanda K. dos Santos Elena Sanchez-Lopez Amanda Cano Aleksandra Zielińska Rafał Staszewski Jacek Karczewski Maria P. D. Gremião Marlus Chorilli Lipid Nanocarriers for Hyperproliferative Skin Diseases
description	Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.
format	article
author	Eliana B. Souto Ana L. R. de Souza Fernanda K. dos Santos Elena Sanchez-Lopez Amanda Cano Aleksandra Zielińska Rafał Staszewski Jacek Karczewski Maria P. D. Gremião Marlus Chorilli
author_facet	Eliana B. Souto Ana L. R. de Souza Fernanda K. dos Santos Elena Sanchez-Lopez Amanda Cano Aleksandra Zielińska Rafał Staszewski Jacek Karczewski Maria P. D. Gremião Marlus Chorilli
author_sort	Eliana B. Souto
title	Lipid Nanocarriers for Hyperproliferative Skin Diseases
title_short	Lipid Nanocarriers for Hyperproliferative Skin Diseases
title_full	Lipid Nanocarriers for Hyperproliferative Skin Diseases
title_fullStr	Lipid Nanocarriers for Hyperproliferative Skin Diseases
title_full_unstemmed	Lipid Nanocarriers for Hyperproliferative Skin Diseases
title_sort	lipid nanocarriers for hyperproliferative skin diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c6b1670306f6441f9db4e770188047d8
work_keys_str_mv	AT elianabsouto lipidnanocarriersforhyperproliferativeskindiseases AT analrdesouza lipidnanocarriersforhyperproliferativeskindiseases AT fernandakdossantos lipidnanocarriersforhyperproliferativeskindiseases AT elenasanchezlopez lipidnanocarriersforhyperproliferativeskindiseases AT amandacano lipidnanocarriersforhyperproliferativeskindiseases AT aleksandrazielinska lipidnanocarriersforhyperproliferativeskindiseases AT rafałstaszewski lipidnanocarriersforhyperproliferativeskindiseases AT jacekkarczewski lipidnanocarriersforhyperproliferativeskindiseases AT mariapdgremiao lipidnanocarriersforhyperproliferativeskindiseases AT marluschorilli lipidnanocarriersforhyperproliferativeskindiseases
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Lipid Nanocarriers for Hyperproliferative Skin Diseases

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