Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.

Guardado en:

Detalles Bibliográficos
Autores principales:	Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv, Shiaoching Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6b3ebba7a6c4cca98a75c5a151f33d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c6b3ebba7a6c4cca98a75c5a151f33d5
record_format	dspace
spelling	oai:doaj.org-article:c6b3ebba7a6c4cca98a75c5a151f33d52021-12-02T16:49:53ZDissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models10.1038/s41467-018-03081-72041-1723https://doaj.org/article/c6b3ebba7a6c4cca98a75c5a151f33d52018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03081-7https://doaj.org/toc/2041-1723The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.Upneet K. SokhiMark P. LiberLaura FryeSungho ParkKyuho KangTania PannelliniBaohong ZhaoRada NorinskyLionel B. IvashkivShiaoching GongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
description	The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.
format	article
author	Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong
author_facet	Upneet K. Sokhi Mark P. Liber Laura Frye Sungho Park Kyuho Kang Tania Pannellini Baohong Zhao Rada Norinsky Lionel B. Ivashkiv Shiaoching Gong
author_sort	Upneet K. Sokhi
title	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_short	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_full	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_fullStr	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_full_unstemmed	Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
title_sort	dissection and function of autoimmunity-associated tnfaip3 (a20) gene enhancers in humanized mouse models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c6b3ebba7a6c4cca98a75c5a151f33d5
work_keys_str_mv	AT upneetksokhi dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT markpliber dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT laurafrye dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT sunghopark dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT kyuhokang dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT taniapannellini dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT baohongzhao dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT radanorinsky dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT lionelbivashkiv dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels AT shiaochinggong dissectionandfunctionofautoimmunityassociatedtnfaip3a20geneenhancersinhumanizedmousemodels
_version_	1718383183672639488

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

Ejemplares similares