Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis

Ulcerative colitis (UC), which affects millions of people worldwide, is characterized by extensive colonic injury involving mucosal and submucosal layers of the colon. Nuclear factor E2-related factor 2 (Nrf2) plays a critical role in cellular protection against oxidant-induced stress. Antioxidant r...

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Autores principales:	Hu Liu, Lee J. Johnston, Fenglai Wang, Xi Ma
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidant response element Kelch-like ECH-associated protein 1 nuclear factor E2-related factor 2 nutritional regulation ulcerative colitis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c6b465b450f8447a9cf1031204e6a039
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spelling	oai:doaj.org-article:c6b465b450f8447a9cf1031204e6a0392021-11-11T16:53:02ZTriggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis10.3390/ijms2221114111422-00671661-6596https://doaj.org/article/c6b465b450f8447a9cf1031204e6a0392021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11411https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Ulcerative colitis (UC), which affects millions of people worldwide, is characterized by extensive colonic injury involving mucosal and submucosal layers of the colon. Nuclear factor E2-related factor 2 (Nrf2) plays a critical role in cellular protection against oxidant-induced stress. Antioxidant response element (ARE) is the binding site recognized by Nrf2 and leads to the expression of phase II detoxifying enzymes and antioxidant proteins. The Nrf2/ARE system is a key factor for preventing and resolving tissue injury and inflammation in disease conditions such as UC. Researchers have proposed that both Keap1-dependent and Keap1-independent cascades contribute positive effects on activation of the Nrf2/ARE pathway. In this review, we summarize the present knowledge on mechanisms controlling the activation process. We will further review nutritional compounds that can modulate activation of the Nrf2/ARE pathway and may be used as potential therapeutic application of UC. These comprehensive data will help us to better understand the Nrf2/ARE signaling pathway and promote its effective application in response to common diseases induced by oxidative stress and inflammation.Hu LiuLee J. JohnstonFenglai WangXi MaMDPI AGarticleantioxidant response elementKelch-like ECH-associated protein 1nuclear factor E2-related factor 2nutritional regulationulcerative colitisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11411, p 11411 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant response element Kelch-like ECH-associated protein 1 nuclear factor E2-related factor 2 nutritional regulation ulcerative colitis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	antioxidant response element Kelch-like ECH-associated protein 1 nuclear factor E2-related factor 2 nutritional regulation ulcerative colitis Biology (General) QH301-705.5 Chemistry QD1-999 Hu Liu Lee J. Johnston Fenglai Wang Xi Ma Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis
description	Ulcerative colitis (UC), which affects millions of people worldwide, is characterized by extensive colonic injury involving mucosal and submucosal layers of the colon. Nuclear factor E2-related factor 2 (Nrf2) plays a critical role in cellular protection against oxidant-induced stress. Antioxidant response element (ARE) is the binding site recognized by Nrf2 and leads to the expression of phase II detoxifying enzymes and antioxidant proteins. The Nrf2/ARE system is a key factor for preventing and resolving tissue injury and inflammation in disease conditions such as UC. Researchers have proposed that both Keap1-dependent and Keap1-independent cascades contribute positive effects on activation of the Nrf2/ARE pathway. In this review, we summarize the present knowledge on mechanisms controlling the activation process. We will further review nutritional compounds that can modulate activation of the Nrf2/ARE pathway and may be used as potential therapeutic application of UC. These comprehensive data will help us to better understand the Nrf2/ARE signaling pathway and promote its effective application in response to common diseases induced by oxidative stress and inflammation.
format	article
author	Hu Liu Lee J. Johnston Fenglai Wang Xi Ma
author_facet	Hu Liu Lee J. Johnston Fenglai Wang Xi Ma
author_sort	Hu Liu
title	Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis
title_short	Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis
title_full	Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis
title_fullStr	Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis
title_full_unstemmed	Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis
title_sort	triggers for the nrf2/are signaling pathway and its nutritional regulation: potential therapeutic applications of ulcerative colitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c6b465b450f8447a9cf1031204e6a039
work_keys_str_mv	AT huliu triggersforthenrf2aresignalingpathwayanditsnutritionalregulationpotentialtherapeuticapplicationsofulcerativecolitis AT leejjohnston triggersforthenrf2aresignalingpathwayanditsnutritionalregulationpotentialtherapeuticapplicationsofulcerativecolitis AT fenglaiwang triggersforthenrf2aresignalingpathwayanditsnutritionalregulationpotentialtherapeuticapplicationsofulcerativecolitis AT xima triggersforthenrf2aresignalingpathwayanditsnutritionalregulationpotentialtherapeuticapplicationsofulcerativecolitis
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Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis

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