Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life.
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Nature Portfolio
2020
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oai:doaj.org-article:c6b4fb64963a4ad99c5b0ef50dad5ac92021-12-02T15:37:09ZNeurology-related protein biomarkers are associated with cognitive ability and brain volume in older age10.1038/s41467-019-14161-72041-1723https://doaj.org/article/c6b4fb64963a4ad99c5b0ef50dad5ac92020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14161-7https://doaj.org/toc/2041-1723Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life.Sarah E. HarrisSimon R. CoxSteven BellRiccardo E. MarioniBram P. PrinsAlison PattieJanie CorleySusana Muñoz ManiegaMaria Valdés HernándezZoe MorrisSally JohnPaola G. BronsonElliot M. Tucker-DrobJohn M. StarrMark E. BastinJoanna M. WardlawAdam S. ButterworthIan J. DearyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sarah E. Harris Simon R. Cox Steven Bell Riccardo E. Marioni Bram P. Prins Alison Pattie Janie Corley Susana Muñoz Maniega Maria Valdés Hernández Zoe Morris Sally John Paola G. Bronson Elliot M. Tucker-Drob John M. Starr Mark E. Bastin Joanna M. Wardlaw Adam S. Butterworth Ian J. Deary Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| description |
Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life. |
| format |
article |
| author |
Sarah E. Harris Simon R. Cox Steven Bell Riccardo E. Marioni Bram P. Prins Alison Pattie Janie Corley Susana Muñoz Maniega Maria Valdés Hernández Zoe Morris Sally John Paola G. Bronson Elliot M. Tucker-Drob John M. Starr Mark E. Bastin Joanna M. Wardlaw Adam S. Butterworth Ian J. Deary |
| author_facet |
Sarah E. Harris Simon R. Cox Steven Bell Riccardo E. Marioni Bram P. Prins Alison Pattie Janie Corley Susana Muñoz Maniega Maria Valdés Hernández Zoe Morris Sally John Paola G. Bronson Elliot M. Tucker-Drob John M. Starr Mark E. Bastin Joanna M. Wardlaw Adam S. Butterworth Ian J. Deary |
| author_sort |
Sarah E. Harris |
| title |
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| title_short |
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| title_full |
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| title_fullStr |
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| title_full_unstemmed |
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| title_sort |
neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c6b4fb64963a4ad99c5b0ef50dad5ac9 |
| work_keys_str_mv |
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