Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy

Abstract Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared...

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Autores principales:	Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe, Theano Papavassiliu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6ba8a5a90b7486fa0c22e5c11bdb369
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spelling	oai:doaj.org-article:c6ba8a5a90b7486fa0c22e5c11bdb3692021-12-02T12:32:01ZIncremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy10.1038/s41598-017-06533-02045-2322https://doaj.org/article/c6ba8a5a90b7486fa0c22e5c11bdb3692017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06533-0https://doaj.org/toc/2045-2322Abstract Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 patients with low, intermediate and high ESC risk scores. In these patients left and right ventricular ejection fraction and volumes were comparable. Patients with a high ESC risk score revealed a significantly higher extent of late gadolinium enhancement (LGE) compared to patients with intermediate or a low risk scores. During follow-up of 4 years an extent of LGE ≥20% identified patients at a higher risk for major adverse cardiac arrhythmic events in the low and intermediate ESC risk group whereas an extent of LGE <20% was associated with a low risk of major adverse cardiac arrhythmic events despite a high ESC risk score ≥6%. Hence, we hypothesize that the extent of fibrosis might be an additional risk marker.Christina DoeschErol TülümenIbrahim AkinBoris RudicJuergen KuschykIbrahim El-BattrawyTobias BecherJohannes BudjanArman SmakicStefan O. SchoenbergMartin BorggrefeTheano PapavassiliuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Doesch Erol Tülümen Ibrahim Akin Boris Rudic Juergen Kuschyk Ibrahim El-Battrawy Tobias Becher Johannes Budjan Arman Smakic Stefan O. Schoenberg Martin Borggrefe Theano Papavassiliu Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
description	Abstract Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 patients with low, intermediate and high ESC risk scores. In these patients left and right ventricular ejection fraction and volumes were comparable. Patients with a high ESC risk score revealed a significantly higher extent of late gadolinium enhancement (LGE) compared to patients with intermediate or a low risk scores. During follow-up of 4 years an extent of LGE ≥20% identified patients at a higher risk for major adverse cardiac arrhythmic events in the low and intermediate ESC risk group whereas an extent of LGE <20% was associated with a low risk of major adverse cardiac arrhythmic events despite a high ESC risk score ≥6%. Hence, we hypothesize that the extent of fibrosis might be an additional risk marker.
format	article
author	Christina Doesch Erol Tülümen Ibrahim Akin Boris Rudic Juergen Kuschyk Ibrahim El-Battrawy Tobias Becher Johannes Budjan Arman Smakic Stefan O. Schoenberg Martin Borggrefe Theano Papavassiliu
author_facet	Christina Doesch Erol Tülümen Ibrahim Akin Boris Rudic Juergen Kuschyk Ibrahim El-Battrawy Tobias Becher Johannes Budjan Arman Smakic Stefan O. Schoenberg Martin Borggrefe Theano Papavassiliu
author_sort	Christina Doesch
title	Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
title_short	Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
title_full	Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
title_fullStr	Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
title_full_unstemmed	Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
title_sort	incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c6ba8a5a90b7486fa0c22e5c11bdb369
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Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy

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