Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity

Mesenchymal stem cells (MSCs) are self-renewable, multipotent stem cells that regulate the phenotype and function of all immune cells that participate in anti-tumor immunity. MSCs modulate the antigen-presenting properties of dendritic cells, affect chemokine and cytokine production in macrophages a...

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Autores principales:	Carl Randall Harrell, Ana Volarevic, Valentin G. Djonov, Nemanja Jovicic, Vladislav Volarevic
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesenchymal stem cells regulation immune response tumor immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c6ba91b62f8645029cc34dd58f8c859f
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spelling	oai:doaj.org-article:c6ba91b62f8645029cc34dd58f8c859f2021-11-25T17:56:34ZMesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity10.3390/ijms2222124291422-00671661-6596https://doaj.org/article/c6ba91b62f8645029cc34dd58f8c859f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12429https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Mesenchymal stem cells (MSCs) are self-renewable, multipotent stem cells that regulate the phenotype and function of all immune cells that participate in anti-tumor immunity. MSCs modulate the antigen-presenting properties of dendritic cells, affect chemokine and cytokine production in macrophages and CD4+ T helper cells, alter the cytotoxicity of CD8+ T lymphocytes and natural killer cells and regulate the generation and expansion of myeloid-derived suppressor cells and T regulatory cells. As plastic cells, MSCs adopt their phenotype and function according to the cytokine profile of neighboring tumor-infiltrated immune cells. Depending on the tumor microenvironment to which they are exposed, MSCs may obtain pro- and anti-tumorigenic phenotypes and may enhance or suppress tumor growth. Due to their tumor-homing properties, MSCs and their exosomes may be used as vehicles for delivering anti-tumorigenic agents in tumor cells, attenuating their viability and invasive characteristics. Since many factors affect the phenotype and function of MSCs in the tumor microenvironment, a better understanding of signaling pathways that regulate the cross-talk between MSCs, immune cells and tumor cells will pave the way for the clinical use of MSCs in cancer immunotherapy. In this review article, we summarize current knowledge on the molecular and cellular mechanisms that are responsible for the MSC-dependent modulation of the anti-tumor immune response and we discuss different insights regarding therapeutic potential of MSCs in the therapy of malignant diseases.Carl Randall HarrellAna VolarevicValentin G. DjonovNemanja JovicicVladislav VolarevicMDPI AGarticlemesenchymal stem cellsregulationimmune responsetumorimmunotherapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12429, p 12429 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells regulation immune response tumor immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mesenchymal stem cells regulation immune response tumor immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999 Carl Randall Harrell Ana Volarevic Valentin G. Djonov Nemanja Jovicic Vladislav Volarevic Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
description	Mesenchymal stem cells (MSCs) are self-renewable, multipotent stem cells that regulate the phenotype and function of all immune cells that participate in anti-tumor immunity. MSCs modulate the antigen-presenting properties of dendritic cells, affect chemokine and cytokine production in macrophages and CD4+ T helper cells, alter the cytotoxicity of CD8+ T lymphocytes and natural killer cells and regulate the generation and expansion of myeloid-derived suppressor cells and T regulatory cells. As plastic cells, MSCs adopt their phenotype and function according to the cytokine profile of neighboring tumor-infiltrated immune cells. Depending on the tumor microenvironment to which they are exposed, MSCs may obtain pro- and anti-tumorigenic phenotypes and may enhance or suppress tumor growth. Due to their tumor-homing properties, MSCs and their exosomes may be used as vehicles for delivering anti-tumorigenic agents in tumor cells, attenuating their viability and invasive characteristics. Since many factors affect the phenotype and function of MSCs in the tumor microenvironment, a better understanding of signaling pathways that regulate the cross-talk between MSCs, immune cells and tumor cells will pave the way for the clinical use of MSCs in cancer immunotherapy. In this review article, we summarize current knowledge on the molecular and cellular mechanisms that are responsible for the MSC-dependent modulation of the anti-tumor immune response and we discuss different insights regarding therapeutic potential of MSCs in the therapy of malignant diseases.
format	article
author	Carl Randall Harrell Ana Volarevic Valentin G. Djonov Nemanja Jovicic Vladislav Volarevic
author_facet	Carl Randall Harrell Ana Volarevic Valentin G. Djonov Nemanja Jovicic Vladislav Volarevic
author_sort	Carl Randall Harrell
title	Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
title_short	Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
title_full	Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
title_fullStr	Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
title_full_unstemmed	Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
title_sort	mesenchymal stem cell: a friend or foe in anti-tumor immunity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c6ba91b62f8645029cc34dd58f8c859f
work_keys_str_mv	AT carlrandallharrell mesenchymalstemcellafriendorfoeinantitumorimmunity AT anavolarevic mesenchymalstemcellafriendorfoeinantitumorimmunity AT valentingdjonov mesenchymalstemcellafriendorfoeinantitumorimmunity AT nemanjajovicic mesenchymalstemcellafriendorfoeinantitumorimmunity AT vladislavvolarevic mesenchymalstemcellafriendorfoeinantitumorimmunity
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Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity

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