Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K

The Hippo signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie /Yap. Here the authors show that PRP4K, a kinase involved in mRNA splicing, phosphorylates Yki/Yap in the nucleus, which prevents its nuclear accumulation and inhibits Hippo signaling.

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Autores principales:	Yong suk Cho, Jian Zhu, Shuangxi Li, Bing Wang, Yuhong Han, Jin Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6bd11b5099e4f61b8cd70b84e0141fc
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spelling	oai:doaj.org-article:c6bd11b5099e4f61b8cd70b84e0141fc2021-12-02T15:33:42ZRegulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K10.1038/s41467-018-04090-22041-1723https://doaj.org/article/c6bd11b5099e4f61b8cd70b84e0141fc2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04090-2https://doaj.org/toc/2041-1723The Hippo signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie /Yap. Here the authors show that PRP4K, a kinase involved in mRNA splicing, phosphorylates Yki/Yap in the nucleus, which prevents its nuclear accumulation and inhibits Hippo signaling.Yong suk ChoJian ZhuShuangxi LiBing WangYuhong HanJin JiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong suk Cho Jian Zhu Shuangxi Li Bing Wang Yuhong Han Jin Jiang Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
description	The Hippo signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie /Yap. Here the authors show that PRP4K, a kinase involved in mRNA splicing, phosphorylates Yki/Yap in the nucleus, which prevents its nuclear accumulation and inhibits Hippo signaling.
format	article
author	Yong suk Cho Jian Zhu Shuangxi Li Bing Wang Yuhong Han Jin Jiang
author_facet	Yong suk Cho Jian Zhu Shuangxi Li Bing Wang Yuhong Han Jin Jiang
author_sort	Yong suk Cho
title	Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
title_short	Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
title_full	Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
title_fullStr	Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
title_full_unstemmed	Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
title_sort	regulation of yki/yap subcellular localization and hpo signaling by a nuclear kinase prp4k
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c6bd11b5099e4f61b8cd70b84e0141fc
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Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K

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