Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
The Hippo signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie /Yap. Here the authors show that PRP4K, a kinase involved in mRNA splicing, phosphorylates Yki/Yap in the nucleus, which prevents its nuclear accumulation and inhibits Hippo signaling.
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2018
|
| Subjects: | |
| Online Access: | https://doaj.org/article/c6bd11b5099e4f61b8cd70b84e0141fc |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|