DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical mechanistic details of the process.

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Autores principales:	Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang, David Maranon, Elizabeth A. Williamson, Robert Hromas, Claudia Wiese, Gary M. Kupfer, Patrick Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6be56908081470bb7bc5319e965b081
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spelling	oai:doaj.org-article:c6be56908081470bb7bc5319e965b0812021-12-02T15:35:08ZDNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response10.1038/s41467-019-10408-52041-1723https://doaj.org/article/c6be56908081470bb7bc5319e965b0812019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10408-5https://doaj.org/toc/2041-1723In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical mechanistic details of the process.Fengshan LiangAdam S. MillerSimonne LongerichCaroline TangDavid MaranonElizabeth A. WilliamsonRobert HromasClaudia WieseGary M. KupferPatrick SungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fengshan Liang Adam S. Miller Simonne Longerich Caroline Tang David Maranon Elizabeth A. Williamson Robert Hromas Claudia Wiese Gary M. Kupfer Patrick Sung DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
description	In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical mechanistic details of the process.
format	article
author	Fengshan Liang Adam S. Miller Simonne Longerich Caroline Tang David Maranon Elizabeth A. Williamson Robert Hromas Claudia Wiese Gary M. Kupfer Patrick Sung
author_facet	Fengshan Liang Adam S. Miller Simonne Longerich Caroline Tang David Maranon Elizabeth A. Williamson Robert Hromas Claudia Wiese Gary M. Kupfer Patrick Sung
author_sort	Fengshan Liang
title	DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
title_short	DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
title_full	DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
title_fullStr	DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
title_full_unstemmed	DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
title_sort	dna requirement in fancd2 deubiquitination by usp1-uaf1-rad51ap1 in the fanconi anemia dna damage response
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c6be56908081470bb7bc5319e965b081
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DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

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