DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical mechanistic details of the process.
Guardado en:
Autores principales: | Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang, David Maranon, Elizabeth A. Williamson, Robert Hromas, Claudia Wiese, Gary M. Kupfer, Patrick Sung |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c6be56908081470bb7bc5319e965b081 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes
por: Marit Orav, et al.
Publicado: (2019) -
USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth
por: Maria E. Gierisch, et al.
Publicado: (2019) -
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
por: Georgia Velimezi, et al.
Publicado: (2018) -
Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
por: Kenichiro Matsuzaki, et al.
Publicado: (2019) -
The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
por: Chih-Chao Liang, et al.
Publicado: (2016)