15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword

Abstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Aberrant expression of 15-lipoxygenase enzyme seems to play an indicative role in the patholo...

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Autores principales:	Mohammad Amin Vaezi, Banafsheh Safizadeh, Amir Reza Eghtedari, Seyedeh Sara Ghorbanhosseini, Mostafa Rastegar, Vahid Salimi, Masoumeh Tavakoli-Yaraki
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	15-lipoxygenase-1 15-lipoxygenase-2 Breast cancer Cell growth Apoptosis Metastasis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c6bf01ac110143989cb71d2da0f0528f
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spelling	oai:doaj.org-article:c6bf01ac110143989cb71d2da0f0528f2021-11-28T12:38:57Z15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword10.1186/s12944-021-01599-21476-511Xhttps://doaj.org/article/c6bf01ac110143989cb71d2da0f0528f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01599-2https://doaj.org/toc/1476-511XAbstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Aberrant expression of 15-lipoxygenase enzyme seems to play an indicative role in the pathology of different cancer types, tumor progression, metastasis, or apoptosis. Based on the fact that breast cancer is one of the most common cancers that imposes a burden of mortality in women also, on the other hand, evidence in experimental models and human studies indicate the emerging role of the 15-lipoxygenase pathway in breast cancer pathogenesis, we present a review of recent findings related to the role of 15- lipoxygenase enzyme and metabolites in breast cancer growth, apoptosis, metastasis, and invasion as well as their local and circulating expression pattern in patients with breast cancer. Our review supports the emerging role of 15- lipoxygenase in molecular and cellular processes regulating breast tumor cell fate with both positive and negative effects.Mohammad Amin VaeziBanafsheh SafizadehAmir Reza EghtedariSeyedeh Sara GhorbanhosseiniMostafa RastegarVahid SalimiMasoumeh Tavakoli-YarakiBMCarticle15-lipoxygenase-115-lipoxygenase-2Breast cancerCell growthApoptosisMetastasisNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	15-lipoxygenase-1 15-lipoxygenase-2 Breast cancer Cell growth Apoptosis Metastasis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	15-lipoxygenase-1 15-lipoxygenase-2 Breast cancer Cell growth Apoptosis Metastasis Nutritional diseases. Deficiency diseases RC620-627 Mohammad Amin Vaezi Banafsheh Safizadeh Amir Reza Eghtedari Seyedeh Sara Ghorbanhosseini Mostafa Rastegar Vahid Salimi Masoumeh Tavakoli-Yaraki 15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
description	Abstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Aberrant expression of 15-lipoxygenase enzyme seems to play an indicative role in the pathology of different cancer types, tumor progression, metastasis, or apoptosis. Based on the fact that breast cancer is one of the most common cancers that imposes a burden of mortality in women also, on the other hand, evidence in experimental models and human studies indicate the emerging role of the 15-lipoxygenase pathway in breast cancer pathogenesis, we present a review of recent findings related to the role of 15- lipoxygenase enzyme and metabolites in breast cancer growth, apoptosis, metastasis, and invasion as well as their local and circulating expression pattern in patients with breast cancer. Our review supports the emerging role of 15- lipoxygenase in molecular and cellular processes regulating breast tumor cell fate with both positive and negative effects.
format	article
author	Mohammad Amin Vaezi Banafsheh Safizadeh Amir Reza Eghtedari Seyedeh Sara Ghorbanhosseini Mostafa Rastegar Vahid Salimi Masoumeh Tavakoli-Yaraki
author_facet	Mohammad Amin Vaezi Banafsheh Safizadeh Amir Reza Eghtedari Seyedeh Sara Ghorbanhosseini Mostafa Rastegar Vahid Salimi Masoumeh Tavakoli-Yaraki
author_sort	Mohammad Amin Vaezi
title	15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
title_short	15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
title_full	15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
title_fullStr	15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
title_full_unstemmed	15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
title_sort	15-lipoxygenase and its metabolites in the pathogenesis of breast cancer: a double-edged sword
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c6bf01ac110143989cb71d2da0f0528f
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15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword

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