Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins

Cilia are hair-like appendages involved in cell motility and sensory reception. Here, the authors report a high resolution cryo-EM structure of the microtubule doublet from motile cilia and identify microtubule inner proteins (MIPs) bound to the inner surface of the doublet that appear to stabilize...

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Autores principales:	Muneyoshi Ichikawa, Dinan Liu, Panagiotis L. Kastritis, Kaustuv Basu, Tzu Chin Hsu, Shunkai Yang, Khanh Huy Bui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6bf466253ae4a448f152879a69ac15a
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spelling	oai:doaj.org-article:c6bf466253ae4a448f152879a69ac15a2021-12-02T14:42:26ZSubnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins10.1038/ncomms150352041-1723https://doaj.org/article/c6bf466253ae4a448f152879a69ac15a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15035https://doaj.org/toc/2041-1723Cilia are hair-like appendages involved in cell motility and sensory reception. Here, the authors report a high resolution cryo-EM structure of the microtubule doublet from motile cilia and identify microtubule inner proteins (MIPs) bound to the inner surface of the doublet that appear to stabilize its structure.Muneyoshi IchikawaDinan LiuPanagiotis L. KastritisKaustuv BasuTzu Chin HsuShunkai YangKhanh Huy BuiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muneyoshi Ichikawa Dinan Liu Panagiotis L. Kastritis Kaustuv Basu Tzu Chin Hsu Shunkai Yang Khanh Huy Bui Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
description	Cilia are hair-like appendages involved in cell motility and sensory reception. Here, the authors report a high resolution cryo-EM structure of the microtubule doublet from motile cilia and identify microtubule inner proteins (MIPs) bound to the inner surface of the doublet that appear to stabilize its structure.
format	article
author	Muneyoshi Ichikawa Dinan Liu Panagiotis L. Kastritis Kaustuv Basu Tzu Chin Hsu Shunkai Yang Khanh Huy Bui
author_facet	Muneyoshi Ichikawa Dinan Liu Panagiotis L. Kastritis Kaustuv Basu Tzu Chin Hsu Shunkai Yang Khanh Huy Bui
author_sort	Muneyoshi Ichikawa
title	Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
title_short	Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
title_full	Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
title_fullStr	Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
title_full_unstemmed	Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
title_sort	subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c6bf466253ae4a448f152879a69ac15a
work_keys_str_mv	AT muneyoshiichikawa subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins AT dinanliu subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins AT panagiotislkastritis subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins AT kaustuvbasu subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins AT tzuchinhsu subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins AT shunkaiyang subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins AT khanhhuybui subnanometreresolutionstructureofthedoubletmicrotubulerevealsnewclassesofmicrotubuleassociatedproteins
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Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins

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