Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels

Neuropsychiatric disorders (NPDs) are a huge burden to the patient, their family, and society. NPDs have been greatly associated with cardio-metabolic comorbidities such as obesity, type-2 diabetes mellitus, dysglycaemia, insulin resistance, dyslipidemia, atherosclerosis, and other cardiovascular di...

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Autores principales:	Rupinder Kaur Sodhi, Raghunath Singh, Yashika Bansal, Mahendra Bishnoi, Ishwar Parhar, Anurag Kuhad, Tomoko Soga
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TRPA1 Neuropsychiatric disorders metabolic disorders appetite control insulin resistance obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c6c34f3680994eb4985ed207521e862a
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spelling	oai:doaj.org-article:c6c34f3680994eb4985ed207521e862a2021-12-01T12:57:17ZIntersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels1664-239210.3389/fendo.2021.771575https://doaj.org/article/c6c34f3680994eb4985ed207521e862a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.771575/fullhttps://doaj.org/toc/1664-2392Neuropsychiatric disorders (NPDs) are a huge burden to the patient, their family, and society. NPDs have been greatly associated with cardio-metabolic comorbidities such as obesity, type-2 diabetes mellitus, dysglycaemia, insulin resistance, dyslipidemia, atherosclerosis, and other cardiovascular disorders. Antipsychotics, which are frontline drugs in the treatment of schizophrenia and off-label use in other NPDs, also add to this burden by causing severe metabolic perturbations. Despite decades of research, the mechanism deciphering the link between neuropsychiatric and metabolic disorders is still unclear. In recent years, transient receptor potential Ankyrin 1 (TRPA1) channel has emerged as a potential therapeutic target for modulators. TRPA1 agonists/antagonists have shown efficacy in both neuropsychiatric disorders and appetite regulation and thus provide a crucial link between both. TRPA1 channels are activated by compounds such as cinnamaldehyde, allyl isothiocyanate, allicin and methyl syringate, which are present naturally in food items such as cinnamon, wasabi, mustard, garlic, etc. As these are present in many daily food items, it could also improve patient compliance and reduce the patients’ monetary burden. In this review, we have tried to present evidence of the possible involvement of TRPA1 channels in neuropsychiatric and metabolic disorders and a possible hint towards using TRPA1 modulators to target appetite, lipid metabolism, glucose and insulin homeostasis and inflammation associated with NPDs.Rupinder Kaur SodhiRaghunath SinghYashika BansalMahendra BishnoiIshwar ParharAnurag KuhadTomoko SogaFrontiers Media S.A.articleTRPA1Neuropsychiatric disordersmetabolic disordersappetite controlinsulin resistanceobesityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRPA1 Neuropsychiatric disorders metabolic disorders appetite control insulin resistance obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	TRPA1 Neuropsychiatric disorders metabolic disorders appetite control insulin resistance obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Rupinder Kaur Sodhi Raghunath Singh Yashika Bansal Mahendra Bishnoi Ishwar Parhar Anurag Kuhad Tomoko Soga Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels
description	Neuropsychiatric disorders (NPDs) are a huge burden to the patient, their family, and society. NPDs have been greatly associated with cardio-metabolic comorbidities such as obesity, type-2 diabetes mellitus, dysglycaemia, insulin resistance, dyslipidemia, atherosclerosis, and other cardiovascular disorders. Antipsychotics, which are frontline drugs in the treatment of schizophrenia and off-label use in other NPDs, also add to this burden by causing severe metabolic perturbations. Despite decades of research, the mechanism deciphering the link between neuropsychiatric and metabolic disorders is still unclear. In recent years, transient receptor potential Ankyrin 1 (TRPA1) channel has emerged as a potential therapeutic target for modulators. TRPA1 agonists/antagonists have shown efficacy in both neuropsychiatric disorders and appetite regulation and thus provide a crucial link between both. TRPA1 channels are activated by compounds such as cinnamaldehyde, allyl isothiocyanate, allicin and methyl syringate, which are present naturally in food items such as cinnamon, wasabi, mustard, garlic, etc. As these are present in many daily food items, it could also improve patient compliance and reduce the patients’ monetary burden. In this review, we have tried to present evidence of the possible involvement of TRPA1 channels in neuropsychiatric and metabolic disorders and a possible hint towards using TRPA1 modulators to target appetite, lipid metabolism, glucose and insulin homeostasis and inflammation associated with NPDs.
format	article
author	Rupinder Kaur Sodhi Raghunath Singh Yashika Bansal Mahendra Bishnoi Ishwar Parhar Anurag Kuhad Tomoko Soga
author_facet	Rupinder Kaur Sodhi Raghunath Singh Yashika Bansal Mahendra Bishnoi Ishwar Parhar Anurag Kuhad Tomoko Soga
author_sort	Rupinder Kaur Sodhi
title	Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels
title_short	Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels
title_full	Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels
title_fullStr	Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels
title_full_unstemmed	Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels
title_sort	intersections in neuropsychiatric and metabolic disorders: possible role of trpa1 channels
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c6c34f3680994eb4985ed207521e862a
work_keys_str_mv	AT rupinderkaursodhi intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels AT raghunathsingh intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels AT yashikabansal intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels AT mahendrabishnoi intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels AT ishwarparhar intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels AT anuragkuhad intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels AT tomokosoga intersectionsinneuropsychiatricandmetabolicdisorderspossibleroleoftrpa1channels
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Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels

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