Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging

Abstract This methodical work describes the measurement and calculation of pulmonary blood volume in mice based on two imaging techniques namely by using magnetic particle imaging (MPI) and cardiac magnetic resonance imaging (MRI). Besides its feasibility aspects that may influence quantitative anal...

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Autores principales:	Michael Gerhard Kaul, Tobias Mummert, Matthias Graeser, Johannes Salamon, Caroline Jung, Enver Tahir, Harald Ittrich, Gerhard Adam, Kersten Peldschus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6c41e2a646c443c92d36f3d0cd9ba50
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spelling	oai:doaj.org-article:c6c41e2a646c443c92d36f3d0cd9ba502021-12-02T15:53:43ZPulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging10.1038/s41598-021-84276-92045-2322https://doaj.org/article/c6c41e2a646c443c92d36f3d0cd9ba502021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84276-9https://doaj.org/toc/2045-2322Abstract This methodical work describes the measurement and calculation of pulmonary blood volume in mice based on two imaging techniques namely by using magnetic particle imaging (MPI) and cardiac magnetic resonance imaging (MRI). Besides its feasibility aspects that may influence quantitative analysis are studied. Eight FVB mice underwent cardiac MRI to determine stroke volumes and anatomic MRI as morphological reference for functional MPI data. Arrival time analyses of boli of 1 µl of 1 M superparamagnetic tracer were performed by MPI. Pulmonary transit time of the bolus was determined by measurements in the right and left ventricles. Pulmonary blood volume was calculated out of stroke volume, pulmonary transit time and RR-interval length including a maximal error analysis. Cardiac stroke volume was 31.7 µl ± 2.3 µl with an ejection fraction of 71% ± 6%. A sharp contrast bolus profile was observed by MPI allowing subdividing the first pass into three distinct phases: tracer arrival in the right ventricle, pulmonary vasculature, and left ventricle. The bolus full width at half maximum was 578 ms ± 144 ms in the right ventricle and 1042 ms ± 150 ms in the left ventricle. Analysis of pulmonary transit time revealed 745 ms ± 81 ms. Mean RR-interval length was 133 ms ± 12 ms. Pulmonary blood volume resulted in 177 µl ± 27 µl with a mean maximal error limit of 27 µl. Non-invasive assessment of the pulmonary blood volume in mice was feasible. This technique can be of specific value for evaluation of pulmonary hemodynamics in mouse models of cardiac dysfunction or pulmonary disease. Pulmonary blood volume can complement cardiac functional parameters as a further hemodynamic parameter.Michael Gerhard KaulTobias MummertMatthias GraeserJohannes SalamonCaroline JungEnver TahirHarald IttrichGerhard AdamKersten PeldschusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Gerhard Kaul Tobias Mummert Matthias Graeser Johannes Salamon Caroline Jung Enver Tahir Harald Ittrich Gerhard Adam Kersten Peldschus Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
description	Abstract This methodical work describes the measurement and calculation of pulmonary blood volume in mice based on two imaging techniques namely by using magnetic particle imaging (MPI) and cardiac magnetic resonance imaging (MRI). Besides its feasibility aspects that may influence quantitative analysis are studied. Eight FVB mice underwent cardiac MRI to determine stroke volumes and anatomic MRI as morphological reference for functional MPI data. Arrival time analyses of boli of 1 µl of 1 M superparamagnetic tracer were performed by MPI. Pulmonary transit time of the bolus was determined by measurements in the right and left ventricles. Pulmonary blood volume was calculated out of stroke volume, pulmonary transit time and RR-interval length including a maximal error analysis. Cardiac stroke volume was 31.7 µl ± 2.3 µl with an ejection fraction of 71% ± 6%. A sharp contrast bolus profile was observed by MPI allowing subdividing the first pass into three distinct phases: tracer arrival in the right ventricle, pulmonary vasculature, and left ventricle. The bolus full width at half maximum was 578 ms ± 144 ms in the right ventricle and 1042 ms ± 150 ms in the left ventricle. Analysis of pulmonary transit time revealed 745 ms ± 81 ms. Mean RR-interval length was 133 ms ± 12 ms. Pulmonary blood volume resulted in 177 µl ± 27 µl with a mean maximal error limit of 27 µl. Non-invasive assessment of the pulmonary blood volume in mice was feasible. This technique can be of specific value for evaluation of pulmonary hemodynamics in mouse models of cardiac dysfunction or pulmonary disease. Pulmonary blood volume can complement cardiac functional parameters as a further hemodynamic parameter.
format	article
author	Michael Gerhard Kaul Tobias Mummert Matthias Graeser Johannes Salamon Caroline Jung Enver Tahir Harald Ittrich Gerhard Adam Kersten Peldschus
author_facet	Michael Gerhard Kaul Tobias Mummert Matthias Graeser Johannes Salamon Caroline Jung Enver Tahir Harald Ittrich Gerhard Adam Kersten Peldschus
author_sort	Michael Gerhard Kaul
title	Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
title_short	Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
title_full	Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
title_fullStr	Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
title_full_unstemmed	Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
title_sort	pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c6c41e2a646c443c92d36f3d0cd9ba50
work_keys_str_mv	AT michaelgerhardkaul pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT tobiasmummert pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT matthiasgraeser pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT johannessalamon pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT carolinejung pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT envertahir pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT haraldittrich pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT gerhardadam pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging AT kerstenpeldschus pulmonarybloodvolumeestimationinmicebymagneticparticleimagingandmagneticresonanceimaging
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Pulmonary blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging

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