Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes

Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes

Two-pore-domain potassium (K<sub>2P</sub>-) channels conduct outward K<sup>+</sup> currents that maintain the resting membrane potential and modulate action potential repolarization. Members of the K<sub>2P</sub> channel family are widely expressed among different...

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Autores principales: Felix Wiedmann, Norbert Frey, Constanze Schmidt
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
K<sub>2P</sub>-channel
TASK-1
TREK-1
two-pore-domain potassium channel
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c6c4252899d64a68b58ca010535dbf5c
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spelling oai:doaj.org-article:c6c4252899d64a68b58ca010535dbf5c2021-11-25T17:08:51ZTwo-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes10.3390/cells101129142073-4409https://doaj.org/article/c6c4252899d64a68b58ca010535dbf5c2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2914https://doaj.org/toc/2073-4409Two-pore-domain potassium (K<sub>2P</sub>-) channels conduct outward K<sup>+</sup> currents that maintain the resting membrane potential and modulate action potential repolarization. Members of the K<sub>2P</sub> channel family are widely expressed among different human cell types and organs where they were shown to regulate important physiological processes. Their functional activity is controlled by a broad variety of different stimuli, like pH level, temperature, and mechanical stress but also by the presence of lipids or pharmacological agents. In patients suffering from cardiovascular diseases, alterations in K<sub>2P</sub>-channel expression and function have been observed, suggesting functional significance and a potential therapeutic role of these ion channels. For example, upregulation of atrial specific K<sub>2P</sub>3.1 (TASK-1) currents in atrial fibrillation (AF) patients was shown to contribute to atrial action potential duration shortening, a key feature of AF-associated atrial electrical remodelling. Therefore, targeting K<sub>2P</sub>3.1 (TASK-1) channels might constitute an intriguing strategy for AF treatment. Further, mechanoactive K<sub>2P</sub>2.1 (TREK-1) currents have been implicated in the development of cardiac hypertrophy, cardiac fibrosis and heart failure. Cardiovascular expression of other K<sub>2P</sub> channels has been described, functional evidence in cardiac tissue however remains sparse. In the present review, expression, function, and regulation of cardiovascular K<sub>2P</sub> channels are summarized and compared among different species. Remodelling patterns, observed in disease models are discussed and compared to findings from clinical patients to assess the therapeutic potential of K<sub>2P</sub> channels.Felix WiedmannNorbert FreyConstanze SchmidtMDPI AGarticleK<sub>2P</sub>-channelTASK-1TREK-1two-pore-domain potassium channelBiology (General)QH301-705.5ENCells, Vol 10, Iss 2914, p 2914 (2021)
institution DOAJ
collection DOAJ
language EN
topic K<sub>2P</sub>-channel
TASK-1
TREK-1
two-pore-domain potassium channel
Biology (General)
QH301-705.5
spellingShingle K<sub>2P</sub>-channel
TASK-1
TREK-1
two-pore-domain potassium channel
Biology (General)
QH301-705.5
Felix Wiedmann
Norbert Frey
Constanze Schmidt
Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
description Two-pore-domain potassium (K<sub>2P</sub>-) channels conduct outward K<sup>+</sup> currents that maintain the resting membrane potential and modulate action potential repolarization. Members of the K<sub>2P</sub> channel family are widely expressed among different human cell types and organs where they were shown to regulate important physiological processes. Their functional activity is controlled by a broad variety of different stimuli, like pH level, temperature, and mechanical stress but also by the presence of lipids or pharmacological agents. In patients suffering from cardiovascular diseases, alterations in K<sub>2P</sub>-channel expression and function have been observed, suggesting functional significance and a potential therapeutic role of these ion channels. For example, upregulation of atrial specific K<sub>2P</sub>3.1 (TASK-1) currents in atrial fibrillation (AF) patients was shown to contribute to atrial action potential duration shortening, a key feature of AF-associated atrial electrical remodelling. Therefore, targeting K<sub>2P</sub>3.1 (TASK-1) channels might constitute an intriguing strategy for AF treatment. Further, mechanoactive K<sub>2P</sub>2.1 (TREK-1) currents have been implicated in the development of cardiac hypertrophy, cardiac fibrosis and heart failure. Cardiovascular expression of other K<sub>2P</sub> channels has been described, functional evidence in cardiac tissue however remains sparse. In the present review, expression, function, and regulation of cardiovascular K<sub>2P</sub> channels are summarized and compared among different species. Remodelling patterns, observed in disease models are discussed and compared to findings from clinical patients to assess the therapeutic potential of K<sub>2P</sub> channels.
format article
author Felix Wiedmann
Norbert Frey
Constanze Schmidt
author_facet Felix Wiedmann
Norbert Frey
Constanze Schmidt
author_sort Felix Wiedmann
title Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
title_short Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
title_full Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
title_fullStr Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
title_full_unstemmed Two-Pore-Domain Potassium (K<sub>2P</sub>-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
title_sort two-pore-domain potassium (k<sub>2p</sub>-) channels: cardiac expression patterns and disease-specific remodelling processes
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/c6c4252899d64a68b58ca010535dbf5c
work_keys_str_mv AT felixwiedmann twoporedomainpotassiumksub2psubchannelscardiacexpressionpatternsanddiseasespecificremodellingprocesses
AT norbertfrey twoporedomainpotassiumksub2psubchannelscardiacexpressionpatternsanddiseasespecificremodellingprocesses
AT constanzeschmidt twoporedomainpotassiumksub2psubchannelscardiacexpressionpatternsanddiseasespecificremodellingprocesses
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