Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year

In most patients with intracerebral hemorrhage (ICH), the hematoma and perihematomal area decrease over the subsequent months but patients continue to exhibit neurological impairments. In this serial imaging study, we characterized microstructural and neurophysiological changes in the ICH-affected b...

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Autores principales:	Muhammad E. Haque, Seth B. Boren, Octavio D. Arevalo, Reshmi Gupta, Sarah George, Maria A. Parekh, Xiurong Zhao, Jaraslow Aronowski, Sean I. Savitz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	intracerebral hemorrhage stroke quantitative susceptibility mapping (QSM) arterial spin labeling diffusion tensor imaging serial magnetic resonance imaging Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c6c528a4bd974ac68bff0941f2cfa715
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spelling	oai:doaj.org-article:c6c528a4bd974ac68bff0941f2cfa7152021-12-01T18:37:35ZLongitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year1664-229510.3389/fneur.2021.764718https://doaj.org/article/c6c528a4bd974ac68bff0941f2cfa7152021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.764718/fullhttps://doaj.org/toc/1664-2295In most patients with intracerebral hemorrhage (ICH), the hematoma and perihematomal area decrease over the subsequent months but patients continue to exhibit neurological impairments. In this serial imaging study, we characterized microstructural and neurophysiological changes in the ICH-affected brain tissues and collected the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Score (mRS), two clinical stroke scale scores. Twelve ICH patients were serially imaged on a 3T MRI at 1, 3, and 12 months (M) after injury. The hematoma and perihematomal volume masks were created and segmented using FLAIR imaging at 1 month which were applied to compute the susceptibilities (χ), fractional anisotropy (FA), mean diffusivity (MD), and cerebral blood flow (CBF) in the same tissues over time and in the matching contralesional tissues. At 3 M, there was a significant (p < 0.001) reduction in hematoma and perihematomal volumes. At 1 M, the χ, FA, and CBF were decreased in the perihematomal tissues as compared to the contralateral side, whereas MD increased. In the hematomal tissues, the χ increased whereas FA, MD, and CBF decreased as compared to the contralesional area at 1 M. Temporally, CBF in the hematoma and perihematomal tissues remained significantly (p < 0.05) lower compared with the contralesional areas whereas MD in the hematoma and χ in the perihematomal area increased. The NIHSS and mRS significantly correlated with hematoma and perihematomal volume but not with microstructural integrity. Our serial imaging studies provide new information on the long-term changes within the brain after ICH and our findings may have clinical significance that warrants future studies.Muhammad E. HaqueSeth B. BorenOctavio D. ArevaloReshmi GuptaSarah GeorgeMaria A. ParekhXiurong ZhaoJaraslow AronowskiSean I. SavitzFrontiers Media S.A.articleintracerebral hemorrhage strokequantitative susceptibility mapping (QSM)arterial spin labelingdiffusion tensor imagingserial magnetic resonance imagingNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intracerebral hemorrhage stroke quantitative susceptibility mapping (QSM) arterial spin labeling diffusion tensor imaging serial magnetic resonance imaging Neurology. Diseases of the nervous system RC346-429
spellingShingle	intracerebral hemorrhage stroke quantitative susceptibility mapping (QSM) arterial spin labeling diffusion tensor imaging serial magnetic resonance imaging Neurology. Diseases of the nervous system RC346-429 Muhammad E. Haque Seth B. Boren Octavio D. Arevalo Reshmi Gupta Sarah George Maria A. Parekh Xiurong Zhao Jaraslow Aronowski Sean I. Savitz Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
description	In most patients with intracerebral hemorrhage (ICH), the hematoma and perihematomal area decrease over the subsequent months but patients continue to exhibit neurological impairments. In this serial imaging study, we characterized microstructural and neurophysiological changes in the ICH-affected brain tissues and collected the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Score (mRS), two clinical stroke scale scores. Twelve ICH patients were serially imaged on a 3T MRI at 1, 3, and 12 months (M) after injury. The hematoma and perihematomal volume masks were created and segmented using FLAIR imaging at 1 month which were applied to compute the susceptibilities (χ), fractional anisotropy (FA), mean diffusivity (MD), and cerebral blood flow (CBF) in the same tissues over time and in the matching contralesional tissues. At 3 M, there was a significant (p < 0.001) reduction in hematoma and perihematomal volumes. At 1 M, the χ, FA, and CBF were decreased in the perihematomal tissues as compared to the contralateral side, whereas MD increased. In the hematomal tissues, the χ increased whereas FA, MD, and CBF decreased as compared to the contralesional area at 1 M. Temporally, CBF in the hematoma and perihematomal tissues remained significantly (p < 0.05) lower compared with the contralesional areas whereas MD in the hematoma and χ in the perihematomal area increased. The NIHSS and mRS significantly correlated with hematoma and perihematomal volume but not with microstructural integrity. Our serial imaging studies provide new information on the long-term changes within the brain after ICH and our findings may have clinical significance that warrants future studies.
format	article
author	Muhammad E. Haque Seth B. Boren Octavio D. Arevalo Reshmi Gupta Sarah George Maria A. Parekh Xiurong Zhao Jaraslow Aronowski Sean I. Savitz
author_facet	Muhammad E. Haque Seth B. Boren Octavio D. Arevalo Reshmi Gupta Sarah George Maria A. Parekh Xiurong Zhao Jaraslow Aronowski Sean I. Savitz
author_sort	Muhammad E. Haque
title	Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
title_short	Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
title_full	Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
title_fullStr	Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
title_full_unstemmed	Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year
title_sort	longitudinal, quantitative, multimodal mri evaluation of patients with intracerebral hemorrhage over the first year
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c6c528a4bd974ac68bff0941f2cfa715
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Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year

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