The first competing risk survival nomogram in patients with papillary renal cell carcinoma
Abstract There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of cancer-specific mortality (CSM) and other-cause mortality (OCM) of pRCC over time...
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Nature Portfolio
2021
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oai:doaj.org-article:c6c76c387806498bbf22549f4124c4c72021-12-02T15:02:40ZThe first competing risk survival nomogram in patients with papillary renal cell carcinoma10.1038/s41598-021-91217-z2045-2322https://doaj.org/article/c6c76c387806498bbf22549f4124c4c72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91217-zhttps://doaj.org/toc/2045-2322Abstract There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of cancer-specific mortality (CSM) and other-cause mortality (OCM) of pRCC over time, and constructed a nomogram predicting the probability of 2-, 3- and 5-year CSM based on competing risk regression. A total of 5993 pRCC patients who underwent nephrectomy between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The 2-, 3-, 5-year CSM rates were 3.2%, 4.4% and 6.5%, respectively, and that of OCM were 3.2%, 5.0% and 9.3%, respectively. The estimates of 5-year cumulative mortality were most pronounced among patients aged > 75 years in OCM (17.0%). On multivariable analyses, age, tumor grade, T stage, N stage, and with or without bone, liver and lung metastases were identified as independent predictors of CSM following surgery and were integrated to generate the nomogram. The nomogram achieved a satisfactory discrimination with the AUCt of 0.730 at 5-year, and the calibration curves presented impressive agreements. Taken together, age-related OCM is a significant portion of all-cause mortality in elderly patients and our nomogram can be used for decision-making and patient counselling.Xing SuNiu-Niu HouLi-Jun YangPeng-Xiao LiXiao-Jian YangGuang-Dong HouXue-Lin GaoShuai-Jun MaFan GuoRui ZhangWu-He ZhangWei-Jun QinFu-Li WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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| topic |
Medicine R Science Q |
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Medicine R Science Q Xing Su Niu-Niu Hou Li-Jun Yang Peng-Xiao Li Xiao-Jian Yang Guang-Dong Hou Xue-Lin Gao Shuai-Jun Ma Fan Guo Rui Zhang Wu-He Zhang Wei-Jun Qin Fu-Li Wang The first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| description |
Abstract There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of cancer-specific mortality (CSM) and other-cause mortality (OCM) of pRCC over time, and constructed a nomogram predicting the probability of 2-, 3- and 5-year CSM based on competing risk regression. A total of 5993 pRCC patients who underwent nephrectomy between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The 2-, 3-, 5-year CSM rates were 3.2%, 4.4% and 6.5%, respectively, and that of OCM were 3.2%, 5.0% and 9.3%, respectively. The estimates of 5-year cumulative mortality were most pronounced among patients aged > 75 years in OCM (17.0%). On multivariable analyses, age, tumor grade, T stage, N stage, and with or without bone, liver and lung metastases were identified as independent predictors of CSM following surgery and were integrated to generate the nomogram. The nomogram achieved a satisfactory discrimination with the AUCt of 0.730 at 5-year, and the calibration curves presented impressive agreements. Taken together, age-related OCM is a significant portion of all-cause mortality in elderly patients and our nomogram can be used for decision-making and patient counselling. |
| format |
article |
| author |
Xing Su Niu-Niu Hou Li-Jun Yang Peng-Xiao Li Xiao-Jian Yang Guang-Dong Hou Xue-Lin Gao Shuai-Jun Ma Fan Guo Rui Zhang Wu-He Zhang Wei-Jun Qin Fu-Li Wang |
| author_facet |
Xing Su Niu-Niu Hou Li-Jun Yang Peng-Xiao Li Xiao-Jian Yang Guang-Dong Hou Xue-Lin Gao Shuai-Jun Ma Fan Guo Rui Zhang Wu-He Zhang Wei-Jun Qin Fu-Li Wang |
| author_sort |
Xing Su |
| title |
The first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| title_short |
The first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| title_full |
The first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| title_fullStr |
The first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| title_full_unstemmed |
The first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| title_sort |
first competing risk survival nomogram in patients with papillary renal cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c6c76c387806498bbf22549f4124c4c7 |
| work_keys_str_mv |
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