ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS

Abstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is...

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Autores principales:	U. V. Kolobovnikova, O. I. Urazova, V. V. Novitsky, L. S. Litvinova, O. V. Voronkova, I. O. Naslednikova, K. O. Mikheeva, M. V. Ignatov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	lung tuberculosis eosinophilia cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c6cd0a8be2da44c09fadde0c7a7ef8e5
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spelling	oai:doaj.org-article:c6cd0a8be2da44c09fadde0c7a7ef8e52021-11-18T08:03:42ZROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-273-278https://doaj.org/article/c6cd0a8be2da44c09fadde0c7a7ef8e52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/487https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is among key factors determining eosinophilic reactions of blood following infection with M. tuberculosis. Blood serum IL-5 concentrations proved to be significantly higher in patients with tuberculosis accompanied by eosinophilia. In these cases, eotaxin is a chemokine, which selectively acts upon eosinophilic cells. Its effects include prolonged persistence of eosinophils in bloodstream, along with initiation of eosinophil adherence to vascular endothelium, thus enabling subsequent migration of eosinophilic leukocytes to the foci of specific granulomatous inflammation. (Med. Immunol., 2011, vol. 13, N 2-3, pp 273-278)U. V. KolobovnikovaO. I. UrazovaV. V. NovitskyL. S. LitvinovaO. V. VoronkovaI. O. NaslednikovaK. O. MikheevaM. V. IgnatovSPb RAACIarticlelung tuberculosiseosinophiliacytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 273-278 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lung tuberculosis eosinophilia cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	lung tuberculosis eosinophilia cytokines Immunologic diseases. Allergy RC581-607 U. V. Kolobovnikova O. I. Urazova V. V. Novitsky L. S. Litvinova O. V. Voronkova I. O. Naslednikova K. O. Mikheeva M. V. Ignatov ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
description	Abstract. The study considers some aspects of pathogenetic mechanisms underlying blood eosinophilic reactions developing in pulmonary tuberculosis, taking into account some novel data obtained by means of modern immunological techniques. It was revealed that IL-5 is among key factors determining eosinophilic reactions of blood following infection with M. tuberculosis. Blood serum IL-5 concentrations proved to be significantly higher in patients with tuberculosis accompanied by eosinophilia. In these cases, eotaxin is a chemokine, which selectively acts upon eosinophilic cells. Its effects include prolonged persistence of eosinophils in bloodstream, along with initiation of eosinophil adherence to vascular endothelium, thus enabling subsequent migration of eosinophilic leukocytes to the foci of specific granulomatous inflammation. (Med. Immunol., 2011, vol. 13, N 2-3, pp 273-278)
format	article
author	U. V. Kolobovnikova O. I. Urazova V. V. Novitsky L. S. Litvinova O. V. Voronkova I. O. Naslednikova K. O. Mikheeva M. V. Ignatov
author_facet	U. V. Kolobovnikova O. I. Urazova V. V. Novitsky L. S. Litvinova O. V. Voronkova I. O. Naslednikova K. O. Mikheeva M. V. Ignatov
author_sort	U. V. Kolobovnikova
title	ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
title_short	ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
title_full	ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
title_fullStr	ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
title_full_unstemmed	ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS
title_sort	role of il-5 and eotaxin in development of blood eosinophilic reaction during pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c6cd0a8be2da44c09fadde0c7a7ef8e5
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ROLE OF IL-5 AND EOTAXIN IN DEVELOPMENT OF BLOOD EOSINOPHILIC REACTION DURING PULMONARY TUBERCULOSIS

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