A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation

A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation

Enantiomeric bridged [2,2,1] bicyclic lactone skeletons and their ring-opening products are important scaffolds widely occurring in both pharmaceutics and biology active compounds. Here the authors show an efficient method for enantioselective construction of these compounds bearing a quaternary ste...

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Autores principales: Shuailong Li, Zhuangxing Li, Mingzheng Li, Lin He, Xumu Zhang, Hui Lv
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c6ce91e781184e7e87fbc8ee624a5a6d
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spelling oai:doaj.org-article:c6ce91e781184e7e87fbc8ee624a5a6d2021-12-02T19:12:27ZA concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation10.1038/s41467-021-25569-52041-1723https://doaj.org/article/c6ce91e781184e7e87fbc8ee624a5a6d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25569-5https://doaj.org/toc/2041-1723Enantiomeric bridged [2,2,1] bicyclic lactone skeletons and their ring-opening products are important scaffolds widely occurring in both pharmaceutics and biology active compounds. Here the authors show an efficient method for enantioselective construction of these compounds bearing a quaternary stereocenter via Rh-catalyzed asymmetric hydroformylation/intramolecular cyclization/ pyridinium chlorochromate oxidation.Shuailong LiZhuangxing LiMingzheng LiLin HeXumu ZhangHui LvNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuailong Li
Zhuangxing Li
Mingzheng Li
Lin He
Xumu Zhang
Hui Lv
A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
description Enantiomeric bridged [2,2,1] bicyclic lactone skeletons and their ring-opening products are important scaffolds widely occurring in both pharmaceutics and biology active compounds. Here the authors show an efficient method for enantioselective construction of these compounds bearing a quaternary stereocenter via Rh-catalyzed asymmetric hydroformylation/intramolecular cyclization/ pyridinium chlorochromate oxidation.
format article
author Shuailong Li
Zhuangxing Li
Mingzheng Li
Lin He
Xumu Zhang
Hui Lv
author_facet Shuailong Li
Zhuangxing Li
Mingzheng Li
Lin He
Xumu Zhang
Hui Lv
author_sort Shuailong Li
title A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
title_short A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
title_full A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
title_fullStr A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
title_full_unstemmed A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
title_sort concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c6ce91e781184e7e87fbc8ee624a5a6d
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