Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms, precision therapeutics that specifically target aberrant cancer pathways have improved patien...

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Autores principales:	Amin Zargar, Samantha Chang, Ankita Kothari, Antoine M. Snijders, Jian-Hua Mao, Jessica Wang, Amanda C. Hernández, Jay D. Keasling, Trever G. Bivona
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2019
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c6cee335543e44e68f4fb0c21199ec3e
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id	oai:doaj.org-article:c6cee335543e44e68f4fb0c21199ec3e
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spelling	oai:doaj.org-article:c6cee335543e44e68f4fb0c21199ec3e2021-12-02T13:59:29ZOvercoming the challenges of cancer drug resistance through bacterial-mediated therapy2095-882X10.1016/j.cdtm.2019.11.001https://doaj.org/article/c6cee335543e44e68f4fb0c21199ec3e2019-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X19300866https://doaj.org/toc/2095-882XDespite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms, precision therapeutics that specifically target aberrant cancer pathways have improved patient outcomes. Nevertheless, a primary cause of unsuccessful cancer therapy remains cancer drug resistance. In this review, we summarize the broad classes of resistance to cancer therapy, particularly pharmacokinetics, the tumor microenvironment, and drug resistance mechanisms. Furthermore, we describe how bacterial-mediated cancer therapy, a bygone mode of treatment, has been revitalized by synthetic biology and is uniquely suited to address the primary resistance mechanisms that confound traditional therapies. Through genetic engineering, we discuss how bacteria can be potent anticancer agents given their tumor targeting potential, anti-tumor activity, safety, and coordinated delivery of anti-cancer drugs. Keywords: Cancer therapy, Synthetic biology, Drug resistance, Bacterial-mediated therapyAmin ZargarSamantha ChangAnkita KothariAntoine M. SnijdersJian-Hua MaoJessica WangAmanda C. HernándezJay D. KeaslingTrever G. BivonaKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 5, Iss 4, Pp 258-266 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Amin Zargar Samantha Chang Ankita Kothari Antoine M. Snijders Jian-Hua Mao Jessica Wang Amanda C. Hernández Jay D. Keasling Trever G. Bivona Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
description	Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms, precision therapeutics that specifically target aberrant cancer pathways have improved patient outcomes. Nevertheless, a primary cause of unsuccessful cancer therapy remains cancer drug resistance. In this review, we summarize the broad classes of resistance to cancer therapy, particularly pharmacokinetics, the tumor microenvironment, and drug resistance mechanisms. Furthermore, we describe how bacterial-mediated cancer therapy, a bygone mode of treatment, has been revitalized by synthetic biology and is uniquely suited to address the primary resistance mechanisms that confound traditional therapies. Through genetic engineering, we discuss how bacteria can be potent anticancer agents given their tumor targeting potential, anti-tumor activity, safety, and coordinated delivery of anti-cancer drugs. Keywords: Cancer therapy, Synthetic biology, Drug resistance, Bacterial-mediated therapy
format	article
author	Amin Zargar Samantha Chang Ankita Kothari Antoine M. Snijders Jian-Hua Mao Jessica Wang Amanda C. Hernández Jay D. Keasling Trever G. Bivona
author_facet	Amin Zargar Samantha Chang Ankita Kothari Antoine M. Snijders Jian-Hua Mao Jessica Wang Amanda C. Hernández Jay D. Keasling Trever G. Bivona
author_sort	Amin Zargar
title	Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
title_short	Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
title_full	Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
title_fullStr	Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
title_full_unstemmed	Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
title_sort	overcoming the challenges of cancer drug resistance through bacterial-mediated therapy
publisher	KeAi Communications Co., Ltd.
publishDate	2019
url	https://doaj.org/article/c6cee335543e44e68f4fb0c21199ec3e
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Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

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