The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Xuan Sha,1,2 Yue Dai,1,2 Xiaoxi Song,1,2 Siwen Liu,1,2 Shuai Zhang,1,2 Jingjing Li1,2 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, People&...

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Autores principales:	Sha X, Dai Y, Song X, Liu S, Zhang S, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mesoporous silica nanomaterials diagnosis drug delivery atherosclerosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c6d372aa10fc4e37812e33c13f802a17
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spelling	oai:doaj.org-article:c6d372aa10fc4e37812e33c13f802a172021-12-02T14:18:08ZThe Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis1178-2013https://doaj.org/article/c6d372aa10fc4e37812e33c13f802a172021-01-01T00:00:00Zhttps://www.dovepress.com/the-opportunities-and-challenges-of-silica-nanomaterial-for-atheroscle-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xuan Sha,1,2 Yue Dai,1,2 Xiaoxi Song,1,2 Siwen Liu,1,2 Shuai Zhang,1,2 Jingjing Li1,2 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Jingjing LiDepartment of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaTel +8651683262623Email qingchao0124@163.comAbstract: Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.Keywords: mesoporous silica, nanomaterials, diagnosis, drug delivery, atherosclerosisSha XDai YSong XLiu SZhang SLi JDove Medical Pressarticlemesoporous silicananomaterialsdiagnosisdrug deliveryatherosclerosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 701-714 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica nanomaterials diagnosis drug delivery atherosclerosis Medicine (General) R5-920
spellingShingle	mesoporous silica nanomaterials diagnosis drug delivery atherosclerosis Medicine (General) R5-920 Sha X Dai Y Song X Liu S Zhang S Li J The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis
description	Xuan Sha,1,2 Yue Dai,1,2 Xiaoxi Song,1,2 Siwen Liu,1,2 Shuai Zhang,1,2 Jingjing Li1,2 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Jingjing LiDepartment of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaTel +8651683262623Email qingchao0124@163.comAbstract: Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.Keywords: mesoporous silica, nanomaterials, diagnosis, drug delivery, atherosclerosis
format	article
author	Sha X Dai Y Song X Liu S Zhang S Li J
author_facet	Sha X Dai Y Song X Liu S Zhang S Li J
author_sort	Sha X
title	The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis
title_short	The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis
title_full	The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis
title_fullStr	The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis
title_full_unstemmed	The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis
title_sort	opportunities and challenges of silica nanomaterial for atherosclerosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c6d372aa10fc4e37812e33c13f802a17
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The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

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