PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.

Prosthetic joint infections (PJI) are still an extremely concerning eventuality after joint replacement surgery; growing antibiotic resistance is also limiting the prophylactic and treatment options. Chlorhexidine (a widely used topical non-antibiotic antimicrobial compound) coatings on silica nanop...

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Autores principales:	Yazan Al Thaher, Hadil Faris Alotaibi, Lirong Yang, Polina Prokopovich
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6de600c089842359d8219de13664ce4
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spelling	oai:doaj.org-article:c6de600c089842359d8219de13664ce42021-12-02T20:14:02ZPMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.1932-620310.1371/journal.pone.0257947https://doaj.org/article/c6de600c089842359d8219de13664ce42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257947https://doaj.org/toc/1932-6203Prosthetic joint infections (PJI) are still an extremely concerning eventuality after joint replacement surgery; growing antibiotic resistance is also limiting the prophylactic and treatment options. Chlorhexidine (a widely used topical non-antibiotic antimicrobial compound) coatings on silica nanoparticles capable of prolonged drug release have been successfully developed and characterised. Such nanocarriers were incorporated into commercial formulation PMMA bone cement (Cemex), without adversely affecting the mechanical performance. Moreover, the bone cement containing the developed nanocarriers showed superior antimicrobial activity against different bacterial species encountered in PJI, including clinical isolates already resistant to gentamicin. Cytocompatibility tests also showed non inferior performance of the bone cements containing chlorhexidine releasing silica nanocarriers to the equivalent commercial formulation.Yazan Al ThaherHadil Faris AlotaibiLirong YangPolina ProkopovichPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257947 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yazan Al Thaher Hadil Faris Alotaibi Lirong Yang Polina Prokopovich PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.
description	Prosthetic joint infections (PJI) are still an extremely concerning eventuality after joint replacement surgery; growing antibiotic resistance is also limiting the prophylactic and treatment options. Chlorhexidine (a widely used topical non-antibiotic antimicrobial compound) coatings on silica nanoparticles capable of prolonged drug release have been successfully developed and characterised. Such nanocarriers were incorporated into commercial formulation PMMA bone cement (Cemex), without adversely affecting the mechanical performance. Moreover, the bone cement containing the developed nanocarriers showed superior antimicrobial activity against different bacterial species encountered in PJI, including clinical isolates already resistant to gentamicin. Cytocompatibility tests also showed non inferior performance of the bone cements containing chlorhexidine releasing silica nanocarriers to the equivalent commercial formulation.
format	article
author	Yazan Al Thaher Hadil Faris Alotaibi Lirong Yang Polina Prokopovich
author_facet	Yazan Al Thaher Hadil Faris Alotaibi Lirong Yang Polina Prokopovich
author_sort	Yazan Al Thaher
title	PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.
title_short	PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.
title_full	PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.
title_fullStr	PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.
title_full_unstemmed	PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.
title_sort	pmma bone cement containing long releasing silica-based chlorhexidine nanocarriers.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c6de600c089842359d8219de13664ce4
work_keys_str_mv	AT yazanalthaher pmmabonecementcontaininglongreleasingsilicabasedchlorhexidinenanocarriers AT hadilfarisalotaibi pmmabonecementcontaininglongreleasingsilicabasedchlorhexidinenanocarriers AT lirongyang pmmabonecementcontaininglongreleasingsilicabasedchlorhexidinenanocarriers AT polinaprokopovich pmmabonecementcontaininglongreleasingsilicabasedchlorhexidinenanocarriers
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PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers.

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