Neopterin: A Promising Candidate Biomarker for Severe COVID-19

Wasihun Hailemichael,1 Mulugeta Kiros,2 Yibeltal Akelew,3 Sisay Getu,4 Henok Andualem1 1Immunology and Molecular Biology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Medical Microbiology, Medical Laboratory Science, College of Health Scienc...

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Autores principales:	Hailemichael W, Kiros M, Akelew Y, Getu S, Andualem H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	neopterin biomarker mas sars-cov-2 covid-19 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c6e1a711221f4865af1cd74103f9b59d
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spelling	oai:doaj.org-article:c6e1a711221f4865af1cd74103f9b59d2021-12-02T12:14:54ZNeopterin: A Promising Candidate Biomarker for Severe COVID-191178-7031https://doaj.org/article/c6e1a711221f4865af1cd74103f9b59d2021-02-01T00:00:00Zhttps://www.dovepress.com/neopterin-a-promising-candidate-biomarker-for-severe-covid-19-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Wasihun Hailemichael,1 Mulugeta Kiros,2 Yibeltal Akelew,3 Sisay Getu,4 Henok Andualem1 1Immunology and Molecular Biology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Medical Microbiology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 3Immunology and Molecular Biology, Medical Laboratory Sciences, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 4Hematology and Immuno-Hematology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaCorrespondence: Wasihun HailemichaelImmunology and Molecular Biology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaTel +251 946111414Email wasihunh383@gmail.comAbstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has rapidly spread across the world since its first emergence in China in late 2019. It is a major public health concern with no effective treatct 3ments. The immunopathology of SARS-CoV-2 is associated with an excessive inflammatory response. Macrophage activation syndrome (MAS) is also associated with the severity of the disease in SARS-CoV-2-infected patients. Neopterin is a macrophage activation marker produced by monocytes and macrophages upon activation by interferon-gamma (IFN-γ). Neopterin is a well-established marker in a variety of diseases, and recent evidence indicates that it could be helpful in early prediction of the severity of COVID-19 disease and serve as a prognostic marker. Here, we outline the role of macrophage activation syndrome in the pathogenesis of SARS-CoV-2 and suggest that neopterin could be used as a biomarker for progression of COVID-19.Keywords: neopterin, biomarker, MAS, SARS-CoV-2, COVID-19Hailemichael WKiros MAkelew YGetu SAndualem HDove Medical Pressarticleneopterinbiomarkermassars-cov-2covid-19PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 245-251 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neopterin biomarker mas sars-cov-2 covid-19 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	neopterin biomarker mas sars-cov-2 covid-19 Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Hailemichael W Kiros M Akelew Y Getu S Andualem H Neopterin: A Promising Candidate Biomarker for Severe COVID-19
description	Wasihun Hailemichael,1 Mulugeta Kiros,2 Yibeltal Akelew,3 Sisay Getu,4 Henok Andualem1 1Immunology and Molecular Biology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Medical Microbiology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 3Immunology and Molecular Biology, Medical Laboratory Sciences, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 4Hematology and Immuno-Hematology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaCorrespondence: Wasihun HailemichaelImmunology and Molecular Biology, Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaTel +251 946111414Email wasihunh383@gmail.comAbstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has rapidly spread across the world since its first emergence in China in late 2019. It is a major public health concern with no effective treatct 3ments. The immunopathology of SARS-CoV-2 is associated with an excessive inflammatory response. Macrophage activation syndrome (MAS) is also associated with the severity of the disease in SARS-CoV-2-infected patients. Neopterin is a macrophage activation marker produced by monocytes and macrophages upon activation by interferon-gamma (IFN-γ). Neopterin is a well-established marker in a variety of diseases, and recent evidence indicates that it could be helpful in early prediction of the severity of COVID-19 disease and serve as a prognostic marker. Here, we outline the role of macrophage activation syndrome in the pathogenesis of SARS-CoV-2 and suggest that neopterin could be used as a biomarker for progression of COVID-19.Keywords: neopterin, biomarker, MAS, SARS-CoV-2, COVID-19
format	article
author	Hailemichael W Kiros M Akelew Y Getu S Andualem H
author_facet	Hailemichael W Kiros M Akelew Y Getu S Andualem H
author_sort	Hailemichael W
title	Neopterin: A Promising Candidate Biomarker for Severe COVID-19
title_short	Neopterin: A Promising Candidate Biomarker for Severe COVID-19
title_full	Neopterin: A Promising Candidate Biomarker for Severe COVID-19
title_fullStr	Neopterin: A Promising Candidate Biomarker for Severe COVID-19
title_full_unstemmed	Neopterin: A Promising Candidate Biomarker for Severe COVID-19
title_sort	neopterin: a promising candidate biomarker for severe covid-19
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c6e1a711221f4865af1cd74103f9b59d
work_keys_str_mv	AT hailemichaelw neopterinapromisingcandidatebiomarkerforseverecovid19 AT kirosm neopterinapromisingcandidatebiomarkerforseverecovid19 AT akelewy neopterinapromisingcandidatebiomarkerforseverecovid19 AT getus neopterinapromisingcandidatebiomarkerforseverecovid19 AT andualemh neopterinapromisingcandidatebiomarkerforseverecovid19
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Neopterin: A Promising Candidate Biomarker for Severe COVID-19

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