Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate.
P-glycoprotein (P-gp) is a 170 kDa transmembrane protein involved in the outward transport of many structurally unrelated substrates. P-gp activation/induction may function as an antidotal pathway to prevent the cytotoxicity of these substrates. In the present study we aimed at testing rifampicin (R...
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Autores principales: | Vânia Vilas-Boas, Renata Silva, Andreia Palmeira, Emília Sousa, Luísa Maria Ferreira, Paula Sério Branco, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/c6e97d15174e4302a22ac65b3b7b8aeb |
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