Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
Pancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells. Myeloid cells in the t...
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2021
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oai:doaj.org-article:c6ea5886473b4e40acf34f6c756e6adf2021-11-12T04:38:59ZMyeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary2352-345X10.1016/j.jcmgh.2021.07.006https://doaj.org/article/c6ea5886473b4e40acf34f6c756e6adf2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352345X2100151Xhttps://doaj.org/toc/2352-345XPancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells. Myeloid cells in the tumor microenvironment inhibit cytotoxic T-cell responses promoting carcinogenesis. Immune checkpoint therapy has not been effective in PDA, most likely because of this robust immune suppression, making it critical to elucidate mechanisms behind this phenomenon. Here, we review myeloid cell infiltration and cellular crosstalk in PDA progression and highlight current therapeutic approaches to target myeloid cell-driven immune suppression.Samantha B. KempMarina Pasca di MaglianoHoward C. CrawfordElsevierarticleDiseases of the digestive system. GastroenterologyRC799-869ENCellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1531-1542 (2021) |
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Diseases of the digestive system. Gastroenterology RC799-869 |
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Diseases of the digestive system. Gastroenterology RC799-869 Samantha B. Kemp Marina Pasca di Magliano Howard C. Crawford Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary |
description |
Pancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells. Myeloid cells in the tumor microenvironment inhibit cytotoxic T-cell responses promoting carcinogenesis. Immune checkpoint therapy has not been effective in PDA, most likely because of this robust immune suppression, making it critical to elucidate mechanisms behind this phenomenon. Here, we review myeloid cell infiltration and cellular crosstalk in PDA progression and highlight current therapeutic approaches to target myeloid cell-driven immune suppression. |
format |
article |
author |
Samantha B. Kemp Marina Pasca di Magliano Howard C. Crawford |
author_facet |
Samantha B. Kemp Marina Pasca di Magliano Howard C. Crawford |
author_sort |
Samantha B. Kemp |
title |
Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary |
title_short |
Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary |
title_full |
Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary |
title_fullStr |
Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary |
title_full_unstemmed |
Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary |
title_sort |
myeloid cell mediated immune suppression in pancreatic cancersummary |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://doaj.org/article/c6ea5886473b4e40acf34f6c756e6adf |
work_keys_str_mv |
AT samanthabkemp myeloidcellmediatedimmunesuppressioninpancreaticcancersummary AT marinapascadimagliano myeloidcellmediatedimmunesuppressioninpancreaticcancersummary AT howardccrawford myeloidcellmediatedimmunesuppressioninpancreaticcancersummary |
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1718431257232146432 |